Alliance for Pandemic Preparedness

June 15, 2021

Antibodies to SARS-CoV-2 in All of Us Research Program Participants, January 2-March 18, 2020

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  • SARS-CoV-2 antibodies were detected in persons from diverse geographic regions in the US prior to the first syndromic cases identified by PCR, according to analysis of samples collected as part of the All of Us study. The All of Us study was started in 2018 and has enrolled a diverse population of US adults from all 50 states. Participation in the study includes repeated collection of blood samples. Using a two-tiered serologic testing algorithm to define seropositive individuals (positive on Abbott with subsequent seropositive on EURUOIMMUN), the authors reanalyzed serum specimens from January to March 2020 and determined that SARS-CoV-2 may have been circulating in Illinois, Wisconsin and Massachusetts as early as January 2020.

Althoff et al. (June 15, 2021). Antibodies to SARS-CoV-2 in All of Us Research Program Participants, January 2-March 18, 2020. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciab519