June 11, 2021

Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2

Category: Article Summary

Topic: Clinical Characteristics and Health Care Setting

Keywords (Tags): children, clinical characteristics

• A retrospective cohort study of persons with SARS-CoV-2 infection diagnosed between April and June 2020 in 7 US states identified 248 cases of multisystem inflammatory syndrome in children (MIS-C) in persons <21 years of age. The corresponding incidence of MIS-C was 5.1 per 100,000 person-months and 316 persons per 1,000,000 (0.0003%) SARS-CoV-2 infections. Incidence was higher among Black, Hispanic or Latino, and Asian or Pacific Islander persons compared to white persons and lower among those aged 16-20 compared to children <5 years of age. The authors indicate that MIS-C was a rare complication associated with SARS-CoV-2 during this time period and suggest that the study can serve as a baseline for monitoring of MIS-C after increased vaccination uptake. 

Payne et al. (June 2021). Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2. JAMA Network Open. https://doi.org/10.1001/jamanetworkopen.2021.16420