Alliance for Pandemic Preparedness

January 20, 2021

Do Antibody Positive Healthcare Workers Have Lower SARS-CoV-2 Infection Rates than Antibody Negative Healthcare Workers Large Multi-Centre Prospective Cohort Study (the SIREN Study) England June to November 2020

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Prior history of SARS-CoV-2 infection was associated with an 83% lower risk of infection in a large, multicenter, prospective cohort study (SIREN) of healthcare workers in England, with median protective effect observed five months following primary infection. The incidence between June 18-November 9, 2020 was 3.3 reinfections per 100,000 person days in the previously-infected cohort, compared with 22.4 new PCR confirmed infections per 100,000 person days in the uninfected cohort. 

Hall et al. (Jan 15, 2021). Do Antibody Positive Healthcare Workers Have Lower SARS-CoV-2 Infection Rates than Antibody Negative Healthcare Workers Large Multi-Centre Prospective Cohort Study (the SIREN Study) England June to November 2020. MedRxiv. https://doi.org/10.1101/2021.01.13.21249642