Alliance for Pandemic Preparedness

February 1, 2021

Mapping a Pandemic SARS-CoV-2 Seropositivity in the United States

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[Pre-print, not peer-reviewed] Between May and July 2020, there were an estimated 4.8 undiagnosed cases of COVID-19 for every case diagnosed in the United States, and an estimated 16.8 million undiagnosed cases by mid-July, based on findings from a serostudy conducted among adults (n = 11,3182) who had not been diagnosed with COVID-19. Undiagnosed seropositivity was highest among those who were younger (ages 18-45, 5.9%), women (5.5%), Black/African American (14.2%), Hispanic (6.1%), and urban residents (5.3%). Seropositivity was higher in locations where there were early outbreaks. During the first wave of infection over the spring/summer of 2020, 4.6% of adults were estimated to have had a prior undiagnosed SARS-CoV-2 infection. 

Kalish et al. (Jan 31, 2021). Mapping a Pandemic SARS-CoV-2 Seropositivity in the United States. Pre-print downloaded Feb 1 from https://doi.org/10.1101/2021.01.27.21250570