Alliance for Pandemic Preparedness

March 9, 2021

Case Fatality Risk of the SARS-CoV-2 Variant of Concern B.1.1.7 in England

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  • [Pre-print, not peer-reviewed] Infection with the SARS-CoV-2 B.1.1.7 variant was associated with 1.7-fold increased risk of death compared to infection with non-B.1.1.7 strains, according to UK electronic health record data collected from November 2020 to February 2021. Increased risk of death was consistent across subgroups by age, number of comorbidities, ethnicity, and deprivation index quintile. Out of 441,161 individuals included in the study, 184,786 (42%) had S-gene target failure indicating B.1.1.7 infection. Among all-cause deaths that occurred during the study, nearly half were among B.1.1.7 cases (419 of 867).  

Grint et al. (Mar 8, 2021). Case Fatality Risk of the SARS-CoV-2 Variant of Concern B.1.1.7 in England. Pre-print downloaded Mar 9 from https://doi.org/10.1101/2021.03.04.21252528