October 23, 2020
Clinical and Epidemiologic Analysis of COVID-19 Children Cases in Colombia PEDIACOVID
At the national level in Colombia, pediatric patients with more severe COVID-19 were significantly younger than those who experienced mild illness or no symptoms. A retrospective analysis found that the mean age of children who had asymptomatic infection was 9.4 years compared to a mean of 4.9 years among those with severe infection and a…
Utilization and Results of Repeat SARS-CoV-2 RT-PCR Testing in a Presumptive Low Prevalence Population
In a population of patients with a low prevalence of SARS-CoV-2 infection, repeat testing of negative patients who had persistent symptoms still yielded a negative result in 96% of the cases. Out of more than 5,000 patients who were tested, 4% of patients were tested more than once, and 96% of those patients were tested…
Tocilizumab in Nonventilated Patients Hospitalized with Covid-19 Pneumonia
[Pre-print, not peer-reviewed] The randomized, placebo-controlled multi-country EMPACTA trial indicated that tocilizumab reduced the likelihood of progression to requiring mechanical ventilation or death in patients who were hospitalized with COVID-19 pneumonia and were not on a ventilator (n=389). The cumulative proportion of patients requiring mechanical ventilation or who had died by day 28 was 12%…
Early Use of Nitazoxanide in Mild Covid-19 Disease Randomized Placebo-Controlled Trial
[Pre-print, not peer-reviewed] A multicenter, randomized, placebo-controlled trial of the antiparasitic drug nitazoxanide indicated that for patients with mild COVID-19, at 1-week follow-up, 78% of patients (n=194) who had received nitazoxanide and 57% who had received placebo (n=198) reported complete resolution of symptoms (p=0.048). Swabs collected were negative for SARS-CoV-2 in 30% of patients in…
Viral Dynamics of SARS-CoV-2 Infection and the Predictive Value of Repeat Testing
[Pre-print, not peer-reviewed] Prospective longitudinal testing for SARS-CoV-2 among players, staff, and vendors associated with the National Basketball Association (n=68) indicated that on average, individuals with symptomatic infection reached similar peak viral RNA concentrations to those with asymptomatic infection (cycle threshold 22.2 vs. 22.4) within similar amounts of time, but acute shedding lasted longer for…
Frequency and Duration of SARS-CoV-2 Shedding in Oral Fluid Samples Assessed by a Modified Commercial Rapid Molecular Assay
A study using the Simplexa COVID-19 Direct assays on oral fluid found that the assay had high sensitivity and specificity to detect SARS-CoV-2 RNA. Simplexa COVID-19 Direct is a rapid assay platform that does not require additional equipment. The assay was used to test oral fluids and nasopharyngeal swab specimens collected in parallel from 164…
Withdrawn: Decrease in Hospitalizations for COVID-19 after Mask Mandates in 1083 U.S. Counties
Withdrawn notice ( https://www.medrxiv.org/content/10.1101/2020.10.21.20208728v2 ) [Pre-print, not peer-reviewed] An analysis of the impact of face mask mandates instituted over the spring and summer in the US indicated that mask mandates across 1,083 counties in the U.S decreased hospitalization rates from COVID-19 even when controlling for other factors that could affect disease severity. Using a staggered…
Adoption of Strategies to Mitigate Transmission of COVID-19 During a Statewide Primary Election — Delaware, September 2020
Survey responses from primary election poll workers in Delaware indicated that SARS-CoV-2 mitigation measures at polling places generally aligned with CDC guidelines and were widely adopted and feasible, but there were some gaps in infection prevention control efforts. Most poll workers surveyed had good knowledge about SARS-CoV-2 transmission and 80% had received COVID-19 mitigation training….
COVID-19 LITERATURE SITUATION REPORT OCT. 23, 2020
Universal mask wearing in the United States could save an additional 129,574 lives from September 22 through the end of February 2021, or 85% mask use could save an additional 95,814 lives when compared to a reference scenario in a model from IHME.
October 22, 2020
Association of the Covid‐19 Lockdown with Smoking, Drinking, and Attempts to Quit in England: An Analysis of 2019‐2020 Data
Cross-sectional surveys of 20,558 adults in the UK administered before and after the COVID-19 lockdown (April 2019-February 2020 and April 2020, respectively) found that the lockdown was not associated with significant changes in smoking prevalence, but was associated with increases in quit attempts, quit success, and cessation among past-year smokers. The lockdown was also associated…
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