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January 22, 2021
Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Pfizer-BioNTech COVID-19 Vaccine
CDC identified 21 case reports of anaphylaxis during the administration of a reported 1,893,360 first doses of Pfizer-BioNTech COVID-19 vaccine between December 14 and 23, 2020. Of these 21 cases, four people (19%) were hospitalized and 17 (81%) were treated in emergency departments. No deaths from anaphylaxis were reported. Seventeen (81%) of 21 patients with…
Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Moderna COVID-19 Vaccine — United States, December 21, 2020–January 10, 2021
Between December 21, 2020 and January 10, 2021, monitoring by the Vaccine Adverse Event Reporting System detected ten cases of anaphylaxis after administration of a reported 4,041,396 first doses of the Moderna COVID-19 vaccine in the US. In nine cases, onset occurred within 15 minutes of vaccination. Nine of the ten cases of anaphylaxis occurred…
Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19
In a phase 2 randomized trial with 577 adult patients with mild to moderate COVID-19, there was no significant difference in the change in SARS-CoV-2 viral load with 3 doses of bamlanivimab, an antispike monoclonal antibody, compared with a placebo. However, treatment with a combination of bamlanivimab and etesevimab, another monoclonal antibody, significantly decreased SARS-CoV-2…
A Cross-Sectional Analysis of Demographic and Behavioral Risk Factors of SARS-CoV-2 Antibody Positivity among a Sample of U.S. College Students
[pre-print, not peer-reviewed] Among undergraduate students at a single college in Indiana, fraternity or sorority membership, having multiple romantic partners, knowing someone with COVID-19, drinking alcohol more than 1 day per week, and attending social gatherings with more than 4 people when drinking alcohol increased both the likelihood of seropositivity and self-reported history of SARS-CoV-2….
January 21, 2021
Vaccination Coverage with Selected Vaccines and Exemption Rates Among Children in Kindergarten — United States, 2019–20 School Year
National vaccination coverage among US kindergarteners was high for the 2019-20 school year, despite most schools shifting to virtual learning in the spring due to the COVID-19 pandemic. Vaccination coverage for state-required number of doses of DTaP, MMR, and varicella (chickenpox) was 94.9%, 95.2%, and 94.8%, respectively. The exemption rate was 2.5%, and only 2.3%…
Association of Social and Economic Inequality With Coronavirus Disease 2019 Incidence and Mortality Across US Counties
A cross-sectional ecologic analysis using US county-level data found that counties with higher income inequality and a higher proportion of Black or Hispanic residents had higher COVID-19 incidence and mortality. Each 1% increase in county-level income inequality, proportion of Black residents, and proportion of Hispanic residents corresponded to 2%, 1.9%, and 2.4% higher incidence and…
Quarantine and Testing Strategies in Contact Tracing for SARS-CoV-2: A Modelling Study
A modeling study found that a shortened quarantine period combined with RT-PCR and antigen testing among SARS-CoV-2 exposed contacts could avert as much transmission as a 14-day quarantine period. In the baseline scenario where 67% of index cases adhere to self-isolation and 50% of exposed contacts adhere to quarantine, a 14-day quarantine period was estimated…
Clinical and Laboratory Features of Hypercoagulability in COVID-19 and Other Respiratory Viral Infections amongst Predominantly Younger Adults with Few Comorbidities
A retrospective cohort study among hospitalized COVID-19 patients (n=181) and patients with other respiratory viral infections (n=165) found similarly low rates of arterial or venous thrombotic events. However, clot waveform analysis parameters were significantly higher among severe than mild COVID-19 patients, suggesting increased risk for hypercoagulability. Patients in the ICU routinely received the thrombosis prevention…
Impact of SARS-CoV-2 B.1.1.7 Spike Variant on Neutralisation
[pre-print, not peer reviewed] Sera from participants who received the first dose of the Pfizer vaccine BNT162b2 three weeks prior had no reduction in neutralizing activity against a pseudovirus with the three key spike protein mutations (N501Y, A570D, and 69/70 deletion) in the SARS-CoV-2 B.1.1.7 variant with higher transmission potential, compared to the wild-type SARS-CoV-2…
Seroprevalence of Anti‐SARS‐CoV‐2 IgG Antibodies in Children with Household Exposure to Adults with COVID‐19: Preliminary Findings
In a study of 30 families with a documented COVID-19 index case, the SARS-CoV-2 seroprevalence based on IgG antibody results was similar among adults (59%) and children (52%), despite twice as many children being previously diagnosed with COVID-19. Seroprevalence was also similar among children <5 (50%) and older than 5 years (54%). Buonsenso et al….
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