Alliance for Pandemic Preparedness

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December 2, 2020

Differential Effects of Antiseptic Mouth Rinses on SARS-CoV-2 Infectivity in Vitro

[Preprint, not peer reviewed] Molecular experiments of several commercially available mouth rinses and antiseptics (Listerine, chlorhexidine gluconate, povidone-iodine, and Colgate Peroxy) found that all products inactivated replication of competent SARS-CoV-2 viruses and pseudotyped viruses expressing spike proteins. The prolonged effect of mouth rinse induced cytotoxicity may impact anti-viral activity.  Xu et al. (Dec 1, 2020)….


Voluntary Adoption of Social Welfare-Enhancing Behavior: Mask-Wearing in Spain during the COVID-19 Outbreak

A nationally representative survey of 4000 citizens in Spain during early stages of the COVID-19 pandemic reported that 49% of respondents wore protective masks either occasionally or very frequently, 10% rarely wore a mask, and 41% never wore a mask. People who were young, had higher educational attainment, reported a lower concern about infection, and…


December 1, 2020

Rapid Disappearance of Influenza Following the Implementation of COVID-19 Mitigation Measures in Hamilton Ontario

[Pre-print, not peer reviewed] Following population-wide implementation of COVID-19 interventions in Hamilton, Ontario, the proportion of samples that tested positive for influenza A and B dropped rapidly to 0% by the week of March 15-21. During the 2010-2019 influenza seasons, the proportion of positive tests reached 0% on a median of the week of May…


COVID-19 Infection among People with HIV in New York City: A Population-Level Analysis of Linked Surveillance Data

While people living with HIV/AIDS (PLWHA) were not overrepresented among COVID-19 cases in New York City (NYC), a greater proportion of PLWHA experienced adverse COVID-19-related outcomes. Lab-confirmed COVID-19 case and death data matched against the NYC HIV surveillance registry identified 2,410 PLWHA (1% of all reported COVID-19 cases vs. 1.5% HIV prevalence in NYC). A…


Unemployment Insurance, Health-Related Social Needs, Health Care Access, and Mental Health During the COVID-19 Pandemic

People living in a household that received unemployment benefits were less likely to have unmet health-related social needs, less likely to have delayed health care, and less likely to be experiencing depressive and anxiety symptoms relative to comparable people not receiving unemployment benefits. These findings were drawn from a cross-sectional study of 68,911 individuals representing…


The Impact of Vaccination on COVID-19 Outbreaks in the United States

[Pre-print, not peer reviewed] In a model parametrized to US demographics and age-specific COVID-19 outcomes, vaccination with 40% coverage prioritizing healthcare workers and high-risk individuals and excluding children under 18 was shown to reduce the overall attack proportion from 7.1% to 1.6%. Vaccination also reduced adverse outcomes, with hospitalizations and deaths decreasing by 85% and…


Increase in Hospital-Acquired Carbapenem-Resistant Acinetobacter Baumannii Infection and Colonization in an Acute Care Hospital During a Surge in COVID-19 Admissions — New Jersey, February–July 2020

A cluster of 34 patients infected with an antibiotic-resistant pathogen primarily associated with hospital-acquired infections was observed in a New Jersey hospital during a surge of COVID-19 hospitalizations in late May 2020. The cluster was linked to deviations in infection prevention and control practices due to pandemic-related resource challenges. Fewer incident cases were reported in…


Race/Ethnicity Among Children With COVID-19–Associated Multisystem Inflammatory Syndrome

Analysis of routine public health surveillance data from March to June 2020 identified an overrepresentation of Black children among those with COVID-19-associated multi-system inflammatory syndrome in children (MIS-C) in New York City (n=223). While Black children constitute 22% of the New York City population, 34% of patients were Black. Additionally, compared with white children, a…


Second versus First Wave of COVID-19 Deaths Shifts in Age Distribution and in Nursing Home Fatalities

[Pre-print, not peer reviewed] Among 11 countries, the age distribution of COVID-19 deaths was similar in the first and second waves. During the second wave, Western European countries and the US tended to have a larger share of deaths among individuals younger than 50 years old (<45 years old in the US). Among 9 countries…


Maternal Coronavirus Infections and Neonates Born to Mothers with SARS-CoV-2: A Systematic Review

In a systematic review (n=70 studies) including 1,457 pregnant women with COVID-19, 39 newborns tested positive for SARS-CoV-2. Among mothers, the most frequent comorbidities were obesity, hypertensive disorders, and gestational diabetes. Premature birth (n=64) and maternal death (n=15) were the most common adverse maternal outcomes, while intrauterine fetal distress (n=28) and intrauterine fetal death and…



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