Article Summary
September 29, 2020
Anti-C5a Antibody IFX-1 (Vilobelimab) Treatment versus Best Supportive Care for Patients with Severe COVID-19 (PANAMO): An Exploratory, Open-Label, Phase 2 Randomised Controlled Trial
An exploratory, open-label, phase 2 randomized trial of the monoclonal antibody IFX-1 (vilobelimab) in adults with severe COVID-19 indicated that C5a inhibition with the drug appeared to be safe. Mortality estimates at 28 days were 13% for the IFX-1 group and 27% for the control group, although the authors note that this outcome is preliminary…
Epidemiological Correlates of PCR Cycle Threshold Values in the Detection of SARS-CoV-2
A study of household transmission from people with mild COVID-19 found that SARS-CoV-2 RNA concentrations were lowest soon after symptoms appeared and increased with time since symptom onset. Viral concentrations were higher in patients under 18 years of age (p=0.01) and those reporting upper respiratory symptoms at the time of sample collection (p=0.001), and were…
September 28, 2020
The Association between Influenza Vaccination and the Risk of SARS-CoV-2 Infection Severe Illness and Death a Systematic Review of the Literature
[Pre-print, not peer-reviewed] A systematic review of 12 studies found that receiving seasonal influenza vaccination was not associated with greater risk of SARS-CoV-2 infection or disease severity in any studies. Several studies found that influenza vaccination was associated with lower risk of SARS-CoV-2 infection, while others found no relationship (7 studies, 242,323 patients). Similarly, several…
Association of Race and Ethnicity With Comorbidities and Survival Among Patients With COVID-19 at an Urban Medical Center in New York
Despite a higher incidence of COVID-19 and a higher proportion of positive test results, non-Hispanic Black and Hispanic patients with COVID-19 had slightly lower risk of death than their non-Hispanic white counterparts (aHR=0.8, p=0.03 for Non-Hispanic Black and aHR=0.7, p=0.002 for Hispanic patients). These findings were based on a cohort study conducted at a medical…
Behavioural Barriers to COVID-19 Testing in Australia
[Pre-print, not peer-reviewed] In a national longitudinal survey in Australia (April-June), 49% of people strongly agreed they would get tested if they had COVID-19 symptoms and 96% agreed to some extent that they would get tested. Common barriers to testing were the belief that testing is painful (11%), not knowing how to get tested (7%),…
COVID-19 in Youth Soccer
[Pre-print, not peer-reviewed] Youth soccer clubs in the US involving 85,861 players that had restarted in-person activities reported 218 COVID-19 cases among their members. None of the cases resulted in hospitalization or death. The authors used these cases to estimate the incidence of COVID-19 among youth soccer athletes and concluded that it was lower than…
Age-Specific COVID-19 Case-Fatality Rate: No Evidence of Changes over Time
Using national-level surveillance data from April to August in Italy, Signorelli and Odone reported the case fatality of COVID-19 varied significantly by age (ranging from 0.1-2.8% in people <60 years up to 29-35% in people ³80 years). However, the age-specific rates were similar over time, as estimated at 2, 4 and 6 months since the onset of…
Racial Disparities in Incidence and Outcomes Among Patients With COVID-19
During 2 weeks in March in Milwaukee, Wisconsin, COVID-19 incidence was higher among Black residents (vs. White: OR=5.4). Adjusting for zip code of residence, Black race (aOR=1.8) and poverty (aOR=3.8) were associated with a greater likelihood of have COVID-19, but only poverty was associated with COVID-19 ICU admission (aOR=3.6). Muñoz-Price et al. (Sept 25, 2020)….
COVID-19 Trends Among School-Aged Children — United States, March 1–September 19, 2020
The incidence of SARS-CoV-2 infection in school-age children increased from March and peaked in July and August, followed by a decline in September. During March 1–September 19, 2020, the US reported a total of 277,285 laboratory-confirmed cases of COVID-19 in school-aged children. The average weekly COVID-19 incidence among adolescents aged 12–17 years was approximately…
Risk Factors Associated with Adverse Fetal Outcomes in Pregnancies Affected by Coronavirus Disease 2019 (COVID-19): A Secondary Analysis of the WAPM Study on COVID-19
The risk of vertical transmission of SARS-CoV-2 was very low in a multinational cohort of 250 neonates born to pregnant women with COVID-19, with only 1 infant (0.4%) testing positive by RT-PCR of pharyngeal swabs performed after delivery. The infant who tested positive was asymptomatic and had a negative RT-PCR test after 14 days of…
Previous page Next page