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August 28, 2020
Clinical Characteristics and Viral RNA Detection in Children with Coronavirus Disease 2019 in the Republic of Korea
Han et al. report a case series of children (age <19 years; n=91) with SARS-CoV-2 across 20 hospitals and 2 isolation facilities across Korea (mid-February to March) and found that 22% of children were asymptomatic. Only 9% of symptomatic cases were diagnosed at the time of symptom onset, while among those with symptoms, 66% had…
Clinical Characteristics of Children and Young People Admitted to Hospital with Covid-19 in United Kingdom: Prospective Multicentre Observational Cohort Study
A prospective observational cohort study in the UK of children and young adults (n=651, median age=4.6, IQR 0.3-13.7) found that 52/456 (11%) participants met the WHO case definition for multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19 (MIS-C). Children who met criteria for MIS-C were older than children who did not (median…
Self-Diagnosed COVID-19 in People with Multiple Sclerosis: A Community-Based Cohort of the UK MS Register
A prospective observational cohort study found that people with multiple sclerosis (MS) and those taking immunomodulatory disease-modifying therapies were not at elevated risk of COVID-19. Among people with MS, 237 of 3,910 (6%) participants reported self-diagnosed COVID-19, which was a similar risk to among their siblings without MS (OR: 1.2, 95%CI: 0.9-1.6). Participants taking disease-modifying…
Low-Dose Hydroxychloroquine Therapy and Mortality in Hospitalized Patients with COVID-19: A Nationwide Observational Study of 8075 Participants
Catteau et al. conducted a retrospective analysis of in-hospital mortality using Belgian national COVID-19 hospital surveillance data (n=8,075) and found that, after adjusting for clinical and demographic features, mortality was lower among patients who received low-dose hydroxychloroquine (2400 mg over 5 days) compared to supportive care alone (HR=0.7, 95%CI: 0.6-0.8). Catteau et al. (Aug 24,…
Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients With COVID-19
A retrospective propensity-matched observational study (n=878) found that famotidine, a histamine-2 blocker used to treat acid reflux and ulcers, was associated with a decreased risk of in-hospital mortality (OR=0.4, 95% CI: 0.2-0.96) as well as combined outcome of death or intubation (OR=0.5, 95% CI: 0.2-0.96). While patients treated with famotidine were younger (63.5 +/- 15…
Systematic Review with Meta-Analysis: SARS-CoV-2 Stool Testing and the Potential for Faecal-Oral Transmission
A systematic review of stool testing for SARS-CoV-2 (95 studies) showed that 934/2149 (43%) patients tested positive by stool sample or by anal swab, with positive results up to 70 days after symptom onset. Fecal samples of 282/443 (64%) remained positive even after respiratory samples became negative, for a mean of 12.5 days, and viable…
August 27, 2020
Population-Scale Longitudinal Mapping of COVID-19 Symptoms, Behaviour and Testing
How We Feel (http://www.howwefeel.org), a web and mobile application, collected 3.6 million longitudinal self-reported survey responses on health, behavior related to the COVID-19 pandemic, and demographics from over 500,000 users across all 50 US states and several US territories (83% female, 76% white) during April 2 – May 12, 2020. Among 3,829 users who used…
Particle Modeling of the Spreading of Coronavirus Disease (COVID-19)
De-Leon and Pederiva present a kinetic Monte Carlo algorithm that shows that a cyclic schedule of no-restrictions/lockdowns that includes at least ten days of lockdown for each cycle can help control SARS-CoV-2 transmission. In particular, this model reduces the infection rate when accompanied by social distancing and complete isolation of symptomatic patients. The comparison between…
Early Pregnancy Mood before and during COVID-19 Community Restrictions among Women of Low Socioeconomic Status in New York City
Women living in low socioeconomic status in New York City showed an improvement in mood in following the implementation of social restrictions in response to the COVID-19 pandemic. Of 488 women who attended their first prenatal appointment between February 3 and June 12, 2020 at the Mount Sinai Hospital in New York, an improvement in…
A Cross-Sectional Survey of Knowledge, Attitude and Practice Associated with COVID-19 among Undergraduate Students in China
A survey of 872 undergraduates from 10 universities in Shanxi, China found that most students were well informed about COVID-19 and exhibited positive attitudes and practices during the outbreak in February. The authors attribute this to effective health education that was delivered through massive public education campaigns. Peng et al. (Aug 26, 2020). A Cross-Sectional…
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