Article Summary
May 18, 2021
Susceptibility and Infectiousness of Children and Adults with SARS-CoV-2 Variant B.1.1.7 Deduced from Three Daycare Centre Outbreaks and Related Household Situations Germany 2021
[Pre-print, not peer-reviewed] Secondary attack rates (SARs) were 17-37% in three kindergarten schools in Germany during three SARS-CoV-2 outbreaks likely caused by the B.1.1.7 variant. A majority (>80%) of secondary cases occurred within 7 days. The pooled household SAR was 37% after excluding single-occupant households and households with another possible index case. Notably, the attack…
Size and Duration of COVID-19 Clusters Go along with a High SARS-CoV-2 Viral Load: A Spatio-Temporal Investigation in Vaud State, Switzerland
Clustering of SARS-CoV-2 cases in Switzerland from January to June 2020 by region and date of diagnosis found that of the 457 clusters with significantly higher risk of infection compared to the surrounding region, 57% had at least one person with extremely high viral load (>1 billion copies/mL). Clusters with the highest viral loads tended…
Serial Interval of COVID-19 and the Effect of Variant B.1.1.7 Analyses from a Prospective Community Cohort Study (Virus Watch)
[Pre-print, not peer-reviewed] The mean interval between exposure to COVID-19 and the development of symptoms was 3.2 days, according to an analysis of 186 likely infector-infectee pairs in England and Wales. The mean serial interval in individuals belonging to households in regions and belonging to study weeks classified as having a high percentage of infections…
Adherence to Masking Requirement During the COVID-19 Pandemic by Early Elementary School Children
Observed mask adherence was on average 77% throughout a school day among pre-K to 2nd grade students participating in in-school instruction in an observational survey (n=1,000) across 15 private schools in Atlanta, GA during Fall 2020. Mask adherence, as observed by teachers for 1,048 classroom days, was lowest among Pre-K students (50-60%) and highest among…
May 17, 2021
Significant Impact of COVID-19 on HIV Care in Hospitals Affecting the First Pillar of the HIV Care Continuum
A study evaluating COVID-19 restrictions in the Netherlands between January and June 2020 found disruptions in clinical HIV care. During lockdown (March 16th through May 31st), there was a significant reduction in the weekly number of HIV tests. The proportion of individuals newly diagnosed with HIV was also lower during lockdown, with a higher proportion…
Risk of COVID-19 Epidemic Resurgence with the Introduction of Vaccination Passes
[Pre-print, not peer-reviewed] A SIR model simulating the impact of vaccine passes or passports on SARS-CoV-2 dynamics found that different restrictions for passholders and unvaccinated individuals can result in a wide variety of epidemic trajectories, some of which may introduce new waves of infections. For example, while passholders may have fewer restrictions initially compared to…
Psychological Distress, Persistent Physical Symptoms, and Perceived Recovery After COVID-19 Illness
Patients experiencing COVID-19-related post-traumatic stress disorder (PTSD) and depression had a higher burden of persistent physical symptoms and were less likely to report feeling recovered 3 months after illness onset, according to a study of adults hospitalized between March 26 and May 27, 2020 in New York. Thirty-six percent of patients reported full recovery from…
A Retrospective Cohort Study of 12,306 Pediatric COVID-19 Patients in the United States
A retrospective cohort study found that among 12,306 pediatric patients with lab-confirmed COVID-19 in the US, 5% were hospitalized, 18% needed critical care services and 4% required mechanical ventilation. 14% experienced gastrointestinal symptoms, 8% had dermatological symptoms (rash), 5% had headache, and 19% had other symptoms (fever, malaise, myalgia, arthralgia and altered smell or taste)….
The Advisory Committee on Immunization Practices’ Interim Recommendation for Use of Pfizer-BioNTech COVID-19 Vaccine in Adolescents Aged 12–15 Years — United States, May 2021
On May 12th, 2021, the Advisory Committee on Immunization Practices (ACIP) made an interim recommendation for the use of the Pfizer-BioNTech vaccine among adolescents aged 12-15, following the expansion of the FDA Emergency Use Authorization age eligibility to include this age group. The ACIP considered evidence from a systematic review of published and unpublished evidence…
Seroconversion Rates Following COVID-19 Vaccination amongst Patients with Malignant Disease- the Impact of Diagnosis and Cancer-Directed Therapies
[Pre-print, not peer-reviewed] Among patients with cancer (n = 201) who were fully vaccinated with the Pfizer-BioNTech, Moderna, or Johnson & Johnson/Janssen vaccines, the majority (94%) showed seroconversion for anti-spike protein IgG. Lower seroconversion frequencies were observed for patients with hematological malignancies (85%), particularly recipients of anti-CD20 therapies (70%) and stem cell transplantation (74%), compared…
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