Article Summary
May 13, 2021
Heterogeneous Magnitude of Immunological Memory to SARS-CoV-2 in Recovered Individuals
SARS-CoV-2-specific cellular and humoral immune responses were maintained up to 5 months post infection in a cohort of professional soccer players in Italy (n=30). 20% of participants displayed weaker immune responses over time, indicating heterogeneity in magnitude of immunological memory. Stronger cellular immune response was associated with symptomatic infection as indicated by higher levels of…
Disparities in COVID-19 Vaccine Initiation and Completion Among Active Component Service Members and Health Care Personnel, 11 December 2020-12 March 2021
Non-Hispanic Black US military service members were 28% less likely to initiate vaccination than non-Hispanic white members, after adjusting for potential confounders. From December 2020 to March 2021 a total of 361,538 service members (27%) initiated a COVID-19 mRNA vaccine. Increasing age, higher education levels, higher military rank, and Asian/Pacific Islander race/ethnicity were also associated…
Covid-19 Vaccine Acceptance in California State Prisons
67% of California prison residents offered a COVID-19 vaccine (n=64,633) accepted at least one dose through March 2021. Acceptance was highest among Hispanic (73%) and white residents (72%), and lowest among Black residents (55%). Acceptance was highest among residents aged ≥65 years and those at high risk for severe COVID-19 (>80%) and lowest among those…
Persisting Salivary IgG against SARS-CoV-2 at 9 Months After Mild COVID-19: A Complementary Approach to Population Surveys
Anti-SARS-CoV-2 spike IgG antibodies were detectable in >85% of saliva samples obtained from 74 mostly mild COVID-19 patients up to 9 months-post symptom onset. Salivary IgG responses were highly correlated with anti-spike IgG. In contrast, anti-nucleocapsid IgG was much lower in samples collected 3 months post symptom onset. In a separate cohort of 147 asymptomatic…
Results of a Shortened Quarantine Protocol on a Midwestern College Campus
No evidence of onward SARS-CoV-2 transmission was observed among college students released from quarantine after 7 days at the University of Notre Dame between September and November 2020. The 7-day quarantine protocol required both a negative PCR test on day 4 and a negative antigen test on day 7. Among 1,130 asymptomatic contacts of index…
Guidance for Fully Vaccinated People
The CDC released updated guidance as of May 13, 2021 that fully vaccinated individuals (2 weeks after a single dose vaccine or 2 weeks after the second dose of a 2-dose vaccine) no longer need to wear face coverings or physically distance in most indoor and outdoor settings regardless of crowd size. Officials at the…
May 12, 2021
Resuming In-Person Classes under COVID-19 Evaluating Assigned Seating Protocols in Limiting Contacts at Postsecondary Institutions
[Pre-print, not peer-reviewed] Simulations of seating arrangements based on student enrollment data from the 2019-2020 academic year at the University of British Columbia found that assigned seating could reduce the mean number of contacts per student to 31 compared to 130 contacts per student with random seating. In combination with assigned seating, excluding large classes…
Evolution of COVID-19 Symptoms during the First 9 Months after Illness Onset
[Pre-print, not peer-reviewed] In a cohort of COVID-19 patients from the Netherlands (n=301) 82% of patients recovering from severe/critical disease reported at least one persistent symptom 12 weeks after illness onset, compared to 33% and 64% among those recovering from mild to moderate disease, respectively. At nine months after illness onset, 42% of participants continued…
Trends over Time in the Risk of Adverse Outcomes among Patients with SARS-CoV-2 Infection
In the 30 days following a positive SARS-CoV-2 test, a decline in hospitalization (44% to 16%) and death (20% to 5%) was observed between February and July 2020 in a cohort of enrollees in the US Veterans Affairs healthcare system (n=55,952). Similar trends were also observed for 30-day incidence for ICU admission and mechanical ventilation….
Passive and Active Immunity in Infants Born to Mothers with SARS-CoV-2 Infection during Pregnancy: Prospective Cohort Study
[Pre-print, not peer-reviewed] In a cohort of US mothers testing positive for SARS-CoV-2 during pregnancy (n=145), anti-SARS-CoV-2 antibodies were detected in 65% and 58% of maternal and cord blood samples at delivery, respectively. The IgG transplacental transfer ratio was significantly higher among women receiving their first maternal positive PCR test 60-180 days before delivery compared…
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