Article Summary
February 27, 2020
Clinical Data on Hospital Environmental Hygiene Monitoring and Medical Staffs Protection during the Coronavirus Disease 2019 Outbreak
The outbreak of COVID-19 placed unprecedented challenges on hospital environmental hygiene and medical staff’s protection in Hospitals China. Jiang et al. assessed hospital environmental hygiene (air and surfaces) using quantitative real RT-PCR methods. Viruses were detected on surfaces in the isolation area with suspected patients and in the air of the isolation ward with an…
De-isolating COVID-19 Suspect Cases: A Continuing Challenge
Tay et al. discuss the challenges of de-isolating COVID-19 suspect cases in Singapore. They report that no single indicator may be effectively used to decide on de-isolation of suspect cases. They provide criteria for de-isolation for COVID-19 suspect cases and conclude that a rigorous framework is required to help clinicians de-isolate COVID-19 patients safely. Tay…
Clinical Features of COVID-19 -Related Liver Damage
Fan et al. warn medical practitioners that COVID-19 may cause liver damage, so treatment with Lopinavir/ritonavir should be administered with caution. Fan et al. (Feb 27, 2020). Clinical Features of COVID-19 -Related Liver Damage. Pre-print downloaded Feb 27 from https://doi.org/10.1101/2020.02.26.20026971
Clinical and radiographic features of cardiac injury in patients with 2019 novel coronavirus pneumonia
Hui and team investigated risk of cardiac injury in patients with 2019 novel coronavirus pneumonia. They reported that cardiac injury was rare among light and mild patients, while common in severe and critical patients. They recommend monitoring heart function in COVID-2019 patients and applying potential interventions for those with abnormal cardiac injury related characteristics. Hui…
Comorbidity and its impact on 1,590 patients with COVID-19 in China: A Nationwide Analysis
He et al. evaluated the spectrum of comorbidities and its impact on the clinical outcome in patients with coronavirus disease 2019 (COVID-19). They report comorbidities were present in 25% of patients with COVID-19 in China and were associated with poorer clinical outcomes. He et al. (Feb 27, 2020). Comorbidity and its impact on 1,590 patients…
Correlation Analysis between Disease Severity and Inflammation-related Parameters in Patients with COVID-19 Pneumonia
Gong et al. analyzed correlation between disease severity and inflammation-related parameters in patients with COVID-19 pneumonia. They analyzed blood inflammation indicators among mild, severe, and critical patients, to help identify severe or critical patients early. They report age, interleukin-2 receptor, C-reactive protein, Ferro-protein, white blood cell and lymphocyte counts should be closely observed. IL-6, TNFα…
Communicating the Risk of Death from Novel Coronavirus Disease (COVID-19)
Kobayashi et al. reviewed key epidemiological problems with using case fatality rate (CFR) and infection fatality rate (IFR) to assess severity of COVID-19. They concluded that division of the cumulative number of deaths by that of cases should be adjusted by the delay in time from illness onset to reporting. They caution that assessing only…
Case fatality rate of novel coronavirus disease 2019 in China
Qi et al. propose calculating case fatality risk by dividing the number of known deaths by the number of confirmed cases “T” days before, where “T” is an average time period from case confirmation to death. This approach could be used for diseases to calculate CFR before a pandemic ends. Qi et al (Feb 26,…
Estimation of country-level basic reproductive ratios for novel Coronavirus (COVID-19) using synthetic contact matrices
Hilton and Keeling, in their estimation of country-level basic reproductive ratios for novel Coronavirus (COVID-19) using synthetic contact matrices, predict that R0 will be highest across Eastern Europe and Japan, and lowest across Africa, Central America and South-Western Asia. They argue that this pattern is largely driven by the demographics; ratio of children to older…
Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV
Xu et al. provide a detailed systematic review and comparison of two animal-to human transmitted human coronaviruses, SARS-COV and SARS-CoV-2, in the context of virus incubation, originations, diagnosis and treatment methods, genomic and proteomic sequences, and pathogenic mechanisms. Xu et al. (Feb 22, 2020). Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV….
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