Article Summary
February 26, 2020
SARS-CoV-2 transmission in cancer patients of a tertiary hospital in Wuhan
1,524 cancer patients were evaluated from Dec 30-Feb 17, of whom 12 developed COVID-19, representing a two-fold greater risk than the general population. Only five of these patients were undergoing cancer treatment, suggesting that hospital visits were likely the most relevant risk factor. Severe illness was not higher than in the general population. Considerations for…
emperature significant change COVID-19 Transmission in 429 cities
This meteorological study found that there may be some effect of temperature on the transmission of COVID-19, which may also help to explain the initial cluster of cases in cases in Wuhan. The authors suggest there may be a nonlinear dose-response relationship between temperature and virus transmission and that colder climates will require stricter control…
February 25, 2020
Effectiveness of intervention strategies for Coronavirus Disease 2019 and an estimation of its 1 peak time
Pan et al. developed two mathematical SEIR models to simulate the current COVID-10 outbreak. The models predicted decline of the basic reproductive number R0 from 5.75 to 1.69 in Wuhan and 6.22 to 1.67 elsewhere in China from 19 January to 16 February 2020. The results also predict the peak of new asymptomatic cases per…
Early phylogenetic estimate of the effective reproduction number of 2019-nCoV
Lai et al used 15 2019-nCoV genomes to reconstruct the evolutionary dynamics of the COVID-19 outbreak, demonstrating the usefulness of phylogeny in supporting the surveillance of emerging new infections even as the epidemic is growing. Lai et al (Feb 23, 2020): Early phylogenetic estimate of the effective reproduction number of 2019-nCoV. Pre-print downloaded Feb 25…
Lessons learned from the 2019-nCoV epidemic on prevention of future infectious Diseases
This report details how Chinese traffic restrictions in Hubei Province. Preliminary data suggest the effectiveness of these restrictions for this outbreak thus far. These measures involved consultation with public health experts, the government, and the general public. This experience will provide valuable lessons for quickly coordinating and coping with future public health emergencies. Pan et…
CDC COVID-19 Response Team: CDC Morbidity and Mortality Weekly Report. Update: Public Health Response to the Coronavirus Disease 2019 Outbreak —United States, February 24, 2020
This MMWR report summarizes U.S. public health efforts slow and to contain transmission of COVID-19. Measures include case and contact identification, recommended assessment, monitoring, and care of travelers arriving from areas with substantial COVID-19 transmission. Interim guidance is available at https://www.cdc.gov/coronavirus/index.html Jernigan (Feb 25, 2020). CDC COVID-19 Response Team: CDC Morbidity and Mortality Weekly Report….
Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR
Lim et al. track the origin of SARS-CoV-2 infections in South Korea. They report on clinical findings and case management of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed. Lim…
Rapid Detection of Novel Coronavirus (COVID-19) by Reverse Transcription-Loop-Mediated Isothermal Amplification
Quantitative reverse transcription PCR (qRT-PCR) is currently the standard for COVID-19 detection; however, Reverse Transcription Loop-Mediated Isothermal Amplification (RTLAMP) may allow for faster and cheaper field based testing at point-of-risk. RT-LAMP can be performed in under 30 mins and specifically detected COVID-19 in simulated patient samples. The test has potential for use in monitoring of…
Viral load of SARS-CoV-2 in clinical samples
The authors report viral dynamics in clinical specimens (throat swabs, sputum, urine, and stool) of 82 COVID-19 patients using N-gene-specific quantitative RT-PCR assay. The findings from viral loads and peak periods of virus in different samples are reported. The timelines when the patients are infectious and when and what type of samples to take for…
Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea
Kim et al. report that data on viral load kinetics in confirmed cases are lacking. They present distinct viral load kinetics of the first two confirmed patients with mild to moderate illnesses in Korea. The findings suggest that viral load kinetics of SARS-CoV-2 may be different from that of other coronavirus infection. Kim et al….
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