Article Summary
February 10, 2020
In Beijing, coronavirus 2019-nCoV has created a siege mentality
This commentary describes the difficult conditions and social environment in Beijing, with some emphasis on the experiences of clinical staff at regional hospitals. Mowbray (Feb 7, 2020). In Beijing, coronavirus 2019-nCoV has created a siege mentality. BMJ. https://doi.org/10.1136/bmj.m516
Public responses to the novel 2019 coronavirus (2019-nCoV) in Japan: mental health consequences and target populations
Social and economic impacts of the 2019-nCoV outbreak are discussed. They are contextualized within the history of emergencies in the region, including atomic bombings, sarin gas attacks, H1N1, and the Fukushima nuclear accident. Anxiety disorders, PTSD, depression, somatization, lower perceived health, public fear, discrimination, and stigmatization are key highlighted as challenges. Shigemura et al. (Feb…
Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China
The 2019-nCoV virus genome has undergone in-depth annotation, and differences between the virus and SARS and SARS-like coronaviruses are described. These differences may explain functional and pathogenic differences between the viruses. Wu et al (Feb 7, 2020). Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2020.02.001
Protein structure and sequence re-analysis of 2019-nCoV genome does not indicate snakes as its intermediate host or the unique similarity between its spike protein insertions and HIV-I
Researchers re-analyzed data reported in two prior papers that suggested snakes are an intermediary host for 2019-nCov. Their results do not support this conclusion, pointing instead to mammals and birds as more likely intermediary hosts. Findings also indicated that the previously reported “unlikely” similarity between a 2019-nCoV spike protein insertion and that of HIV-I was…
Molecular Diagnosis of a Novel Coronavirus (2019-nCoV) Causing an Outbreak of Pneumonia
Researchers developed two 1-step real-time RT PCR assays for the Sarbecovirus subgenus to account for potential genetic diversity of the 2019-nCoV circulating in humans. Assays were tested on respiratory samples and results are promising. Further testing is needed. Lo and Chiu offer some commentary and critique of this earlier report and opportunities for further testing. …
A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)
Following WHO rules for guideline development, this team developed rapid advice guidelines for 2019-nCoV that include epidemiologic characteristics along with recommendations for disease screening and population prevention, diagnosis, treatment and control, nosocomial infection prevention and control, and nursing. This rich tool includes some specific information from Zhongnan Hospital of Wuhan University. Jin et al. (Feb…
Persistence of coronaviruses on inanimate surfaces and its inactivation with biocidal agents
Authors conducted a literature review to determine the ability of coronaviruses to persist on inanimate objects, with potential applications for the current 2019-nCoV outbreak. Both SARS and MERS coronaviruses can persist on inanimate surfaces (fomites) for up to 9 days. They can be inactivated effectively by disinfection procedures with 62-71% ethanol, 0.5% hydrogen peroxide, or…
A contingency plan for the management of the 2019 novel coronavirus outbreak in neonatal intensive care units
A Chinese team provides recommendations for addressing 2019-nCoV preparedness and response in neonatology intensive care units based on prior experiences with coronavirus outbreaks. Wang et al. (Feb 7, 2020). A contingency plan for the management of the 2019 novel coronavirus outbreak in neonatal intensive care units. The Lancet. https://doi.org/10.1016/S2352-4642(20)30040-7
Epidemiologic and Clinical Characteristics of Novel Coronavirus Infections Involving 13 Patients Outside Wuhan, China
Clinical characteristics of 15 2019-nCoV patients outside of Wuhan are described. Chang et al. (Feb 7, 2020). Epidemiologic and Clinical Characteristics of Novel Coronavirus Infections Involving 13 Patients Outside Wuhan, China. JAMA Research Letter. https://jamanetwork.com/journals/jama/fullarticle/2761043?resultClick=1
CT Manifestations of Two Cases of 2019 Novel Coronavirus (2019-nCoV) Pneumonia
CT imaging for two 2019-nCoV patients demonstrate changes over the duration of disease. Fang et al. (Feb 7, 2020). CT Manifestations of Two Cases of 2019 Novel Coronavirus (2019-nCoV) Pneumonia. Radiology. https://pubs.rsna.org/doi/10.1148/radiol.2020200280
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