Article Summary
March 8, 2021
Economic Benefits of COVID-19 Screening Tests with a Vaccine Rollout
[Pre-print, not peer-reviewed] Implementing a nationwide SARS-CoV-2 testing program in the presence of vaccine distribution was projected to potentially save 20,000 lives and increase the US GDP by 2 to 8 times the incremental cost of the tests, according to an economic model that assumed 75% of the US population would be vaccinated by August…
COVID-19 and the Risk for Increased Intimate Partner Violence Among Gay, Bisexual and Other Men Who Have Sex With Men in the United States
Results from a survey of gay, bisexual, and other men who have sex with men (GBMSM) conducted online from April to May 2020 indicated that in March-May 2020, 12.6% of participants reported experiencing any intimate partner violence (IPV), with higher rates of emotional IPV (10.3%) than sexual (2.2%) or physical (1.8%) IPV. Among those who reported…
A Systematic Review and Meta-Analysis of Longitudinal Cohort Studies Comparing Mental Health before versus during the COVID-19 Pandemic
[Pre-print, not peer-reviewed] A systematic review and meta-analysis of longitudinal cohort studies (n = 56) comparing mental health before and during the COVID-19 pandemic showed that there was an overall increase in mental health symptoms that was most pronounced in March-April 2020 (standardized mean change (SMC) = .102) before significantly declining over time (May-July SMC…
Outcomes and Mortality Among Adults Hospitalized With COVID-19 at US Medical Centers
A cohort study of 192,550 adults with COVID-19 admitted to US medical centers between March 1 and August 31, 2020 revealed that in-hospital mortality was 13.6% for the cohort. Mortality increased with age; 1.4% of patients aged 18 to 29 years died while 26.6% 80 years or older died. Among ICU patients, 27.8% died. However,…
Body Mass Index and Risk for COVID-19–Related Hospitalization, Intensive Care Unit Admission, Invasive Mechanical Ventilation, and Death — United States, March–December 2020
Among 148,494 U.S. adults diagnosed with COVID-19 between March-December 2020, individuals with a BMI near the threshold between healthy weight and overweight generally had the lowest risks for hospitalization, ICU admission, and death, with higher risks associated with higher BMI. Obesity was a risk factor for hospitalization and death, particularly among adults aged <65 years….
Robust SARS-CoV-2-Specific T Cell Immunity Is Maintained at 6 Months Following Primary Infection
Functional SARS-CoV-2-specific T cell responses were retained 6 months after initial SARS-CoV-2 infection among 100 convalescent donors between March and April 2020. Interferon (IFN)-γ ELISPOT analysis was used to determine the magnitude of the T cell response. Cell responses were present among all donors and characterized by predominant CD4+ T cell responses with strong interleukin…
Comparison of IgG and Neutralizing Antibody Responses after One or Two Doses of COVID-19 MRNA Vaccine in Previously Infected and Uninfected Persons
[Pre-print, not peer-reviewed] A community-based, home-collected, longitudinal serosurvey of 290 participants before and after vaccination with either the Moderna or Pfizer/BioNTech vaccines found that a prior outpatient COVID-19 diagnosis was associated with strong anti-spike RBD IgG and in vitro neutralizing responses after one vaccine dose. Median IgG concentration and percent neutralization after one dose were…
An Increase in Willingness to Vaccinate against COVID-19 in the US between October 2020 and February 2021 Longitudinal Evidence from the Understanding America Study
[Pre-print, not peer-reviewed] Willingness to be vaccinated against COVID-19 increased in the US from October 2020 to February 2021 according to results from a nationally-representative internet-panel of US adults (n = 7,840 participants). Between April and October 2020, there was a sharp decline in willingness to be vaccinated (from 74% to 53%), followed by a…
Rapid Increase of SARS-CoV-2 Variant B.1.1.7 Detected in Sewage Samples from England between October 2020 and January 2021
[Pre-print, not peer-reviewed] Between October 2020 and January 2021, a rapid increase in the SARS-CoV-2 variant B.1.1.7 was detected in sewage samples in England. Viral RNA containing B.1.1.7 mutations was first identified in a sample collected in London on November 10 and detected in 7-9% of all sewage samples in November, increasing to >95% by January…
Impact of Remdesivir on 28 Day Mortality in Hospitalized Patients with COVID-19 February 2021 Meta-Analysis
[Pre-print, not peer-reviewed] A meta-analysis of peer-reviewed randomized controlled trials (n = 4 studies, 7,333 patients) did not find differences in survival between patients receiving remdesivir versus usual care or placebo (OR = 0.89, 95% CI 0.65-1.21). Considerable variability in illness severity was noted, with between 0-27% of patients mechanically ventilated at the time of…
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