COVID-19 Literature Situation Report
COVID-19 Literature Situation Report is a daily (M-F) newsletter that provides a succinct summary of the latest scientific literature related to the COVID-19 pandemic.
The scientific literature on COVID-19 is rapidly evolving and these articles were selected for review based on their relevance to Washington State decision making around COVID-19 response efforts. Included in these Lit Reps are some manuscripts that have been made available online as pre-prints but have not yet undergone peer review. Please be aware of this when reviewing articles included in the Lit Reps.
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January 19, 2021
COVID-19 Literature Situation Report Jan 19, 2021
The sensitivity of the BinaxNOW antigen test to detect people infected with SARS-CoV-2, compared with RT-PCR, was 35.8% among asymptomatic persons and 64.2% among and symptomatic persons. Specificity was near 100% in both groups. Sensitivity was higher among specimens positive for viral culture.
January 15, 2021
COVID-19 Literature Situation Report Jan 15, 2021
A more highly transmissible variant of SARS-CoV-2, lineage B.1.1.7, has been confirmed in 76 cases in the United States as of January 13, 2021. Models suggest that this variant has potential to drive a new phase of exponential growth in cases in the US, and that even if vaccination protects against infection, substantial transmission of the variant will continue until it becomes the dominant strain.
January 14, 2021
COVID-19 Literature Situation Report Jan 14, 2021
Interim results of the phase 1-2a trial of the Johnson & Johnson adenovirus vector vaccine (Ad26.COV2.S) showed SARS-CoV-2 neutralizing-antibody titers were detected in 90% or more of all participants on day 29 after the first dose and reached 100% by day 57 regardless of age or dose group. The most frequent adverse events included fatigue, headache, and fever.
January 13, 2021
COVID-19 Literature Situation Report Jan 13, 2021
During March 1–December 12, 2020, a total of 2,871,828 laboratory-confirmed cases of COVID-19 in young people aged 0–24 years were reported in the United States, with the majority (57%) occurring among those aged 18–24 years. Temporal incidence patterns suggest that young adults might contribute more to community transmission than do younger children.
January 12, 2021
COVID-19 Literature Situation Report Jan 12, 2021
Rates of pediatric hospitalization for COVID-19 varied considerably across states from May to November 2020. In May, rates ranged from 0 per 100,000 (HI and RI) to 5.4 per 100,000 (NJ) and in November ranged from 3.4 per 100,000 (NH) to 32.8 per 100,000 (AZ). Some states experienced a rapid increase in rates, with Utah experiencing a 5,067% increase (from 0.3 to 15.5 per 100,000) within 3 months.
January 11, 2021
COVID-19 Literature Situation Report Jan 11, 2021
Among collegiate athletes exposed to COVID-19 (n=1,830), one quarter had positive test results during quarantine with a mean of 3.8 days from quarantine start until the positive test result.
January 8, 2021
COVID-19 Literature Situation Report Jan 8, 2021
Transmission of SARS-CoV-2 increased rapidly at an Arkansas university within two weeks of the start of the 2020-2021 academic year, likely facilitated by congregate living settings and gatherings, particularly fraternity and sorority recruitment activities.
January 7, 2021
COVID-19 Literature Situation Report Jan 7, 2021
Anti-spike and anti-RBD IgG antibodies persisted up to 6-8 months post-symptom onset in 90% and 88% of individuals, respectively. Paired timepoint analysis showed that anti-spike and anti-RBD IgG declined with a half-life of 68 and 69 days, respectively.
January 6, 2021
COVID-19 Literature Situation Report Jan 6, 2021
An analysis combing seroprevalence data with reported cases estimated 46,910,006 SARS-CoV-2 total infections, 28,122,752 symptomatic infections, 956,174 hospitalizations, and 304,915 deaths occurred in the US through November 15, 2020. The authors estimate that 14% of Americans were infected with COVID-19 by mid-November.
January 5, 2021
COVID-19 Literature Situation Report Jan 5, 2021
Mutations in three main epitopes of the SARS-CoV-2 spike receptor-binding domain (RBD) affect neutralizing activity of convalescent serum. Mutations occurring at the E484 site had the biggest average effect with a >10-fold reduction in serum neutralization in some donors. The impact of specific viral mutations on neutralization varied substantially across individuals and within the same individual over time, with no mutation completely eliminating neutralizing activity.
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