Alliance for Pandemic Preparedness

COVID-19 Literature Situation Report

COVID-19 Literature Situation Report is a daily (M-F) newsletter that provides a succinct summary of the latest scientific literature related to the COVID-19 pandemic.

The scientific literature on COVID-19 is rapidly evolving and these articles were selected for review based on their relevance to Washington State decision making around COVID-19 response efforts. Included in these Lit Reps are some manuscripts that have been made available online as pre-prints but have not yet undergone peer review. Please be aware of this when reviewing articles included in the Lit Reps.

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May 17, 2021

COVID-19 Literature Situation Report May 17, 2021

Interim results from a large study of US healthcare personnel indicated that one dose of either the Pfizer-BioNTech or Moderna vaccines was 82% effective against symptomatic COVID-19 and 2 doses were 94% effective.


May 14, 2021

COVID-19 Literature Situation Report May 14, 2021

An in vitro study of serum neutralization after two doses of the Pfizer-BioNTech vaccine found that variants B.1.526, B.1.429, and B.1.1.7+E484K remained susceptible to vaccine-elicited neutralizing antibodies, indicating that the E484K mutation, also found in the B.1.351 and B.1.526 lineages, may not compromise the neutralization of vaccine-induced antibodies.


May 13, 2021

COVID-19 Literature Situation Report May 13, 2021

The CDC released updated guidance on May 13, 2021 that fully vaccinated individuals no longer need to wear face coverings or physically distance in most indoor and outdoor settings regardless of crowd size. Mask wearing is still recommended in certain indoor settings, such as healthcare facilities, transportation hubs, and correctional facilities. Fully vaccinated people should continue to follow any applicable federal, state, local, tribal, or territorial laws, rules, and regulations.


May 12, 2021

COVID-19 Literature Situation Report May 12, 2021

Among nearly 2.5 million contacts of over 1 million SARS-CoV-2 index cases in England, index cases with lower cycle threshold values (suggesting higher viral loads) tended to have higher attack rates. Attack rates were 55% higher among index cases with S gene target failure (proxy for the B.1.1.7 variant), and highest among household contacts (9%). Contacts of children were the least likely to test positive.


May 11, 2021

COVID-19 Literature Situation Report May 11, 2021

COVID-19 patients with type 2 diabetes were at a greater than 2-fold elevated risk of COVID-19-related hospitalization, admission to ICU, and death compared to age- and sex- matched controls in a nationwide study in Sweden. COVID-19 patients with type 1 diabetes were at similarly increased risk when compared to matched controls, but unlike type 2 diabetes, there was no independent risk after adjustment for sociodemographic factors, pharmacological treatment, and comorbidities.


May 10, 2021

COVID-19 Literature Situation Report May 10, 2021

Among Italian patients (n=286) who recovered from mild-to-moderate symptomatic COVID-19, the prevalence of altered sense of smell or taste one year after initial symptom onset was more than 20%.


May 7, 2021

COVID-19 Literature Situation Report May 7, 2021

A prospective cohort study of SpaceX employees (N=4,111) found a 91% lower odds of SARS-CoV-2 reinfection over 6 months of follow-up among participants with detectable SARS-CoV-2 antibodies at baseline, potentially indicating that previous infection provides at least 6 months of protection from SARS-CoV-2 reinfection for most individuals.


May 6, 2021

COVID-19 Literature Situation Report May 6, 2021

The Pfizer-BioNTech vaccine was estimated to be 90% effective against the B.1.1.7 SARS-CoV-2 variant and 75% effective against the B.1.351 variant 14 days or more after the second dose in Qatar. Estimated vaccine effectiveness against severe, critical, or fatal SARS-CoV-2 infection caused by any variant was 97%.


May 5, 2021

COVID-19 Literature Situation Report May 5, 2021

The proportions of persons infected with the SARS-CoV-2 B.1.526 variant (first identified in New York) who have poor clinical outcomes does not appear different from other circulating strains. Both breakthrough infections in fully vaccinated persons and possible reinfections were rare, but did not appear more common with the variant.


May 4, 2021

COVID-19 Literature Situation Report May 4, 2021

A transmission model based on CDC modeling tools found that in a pre-K-12 school setting in the US, layering mitigation strategies with contact tracing to produce a net effectiveness of 69% could result in a cumulative incidence of SARS-CoV-2 infection of less 0.9% over 6 months when community incidence is low. Across all scenarios of mitigation strategies and community incidence, hospitalizations did not exceed 0.5% of the school population.



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