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Tag: antibodies
January 27, 2021
Kinetics and Correlates of the Neutralizing Antibody Response to SARS-CoV-2Kinetics and Correlates of the Neutralizing Antibody Response to SARS-CoV-2Kinetics and Correlates of the Neutralizing Antibody Response to SARS-CoV-2
[Pre-print, not per-reviewed] A longitudinal study of people who had recovered from COVID-19 (n=963) estimated a half-life of 7.7 months for anti-spike IgG and a half-life of 8.7 months for serum neutralization, with only 13% of individuals losing seroreactivity at ten months. In addition, around 3% of recovered patients demonstrated effective cross-neutralizing IgG antibodies to…
Increased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization
[Pre-print, not per-reviewed] The SARS-CoV-2 variant B.1.1.7 (UK) was resistant to neutralization by several monoclonal antibodies (mAbs) targeting either the N-terminal domain (NTD) of the virus’s spike protein or its receptor-binding domain (RBD). This variant was also modestly more resistant to neutralization with convalescent plasma (about 3 fold) and sera from people who had received…
January 15, 2021
Seroprevalence and Correlates of SARS-CoV-2 Antibodies in Health Care Workers in Chicago
A study conducted among hospital workers in Illinois in May and June 2020 (n=6510) found that support service workers (10.4%), medical assistants (10.1%), and nurses (7.6%) had significantly higher prevalence of COVID-19 seropositivity than administrators (3.3%). Among participants who had a family member in their home who tested positive for COVID-19 (n=93), 54% were seropositive….
January 13, 2021
Duration and Key Determinants of Infectious Virus Shedding in Hospitalized Patients with Coronavirus Disease-2019 (COVID-19)
A study of 129 hospitalized individuals who had been diagnosed with COVID-19 by RT-PCR detected infectious virus shedding by viral culture in 23 patients (18%), with infectious virus shedding for a median of 8 days after onset of symptoms. Multivariate analyses identified viral loads above 7 log10 RNA copies/mL as independently associated with isolation of infectious…
January 8, 2021
Misinformation about COVID-19: Evidence for Differential Latent Profiles and a Strong Association with Trust in Science
Agley et al. found that believing misinformation about SARS-CoV-2 may not keep people from simultaneously believing in the scientifically accepted explanation for the novel virus’s origins. Among a sample of 660 US-based users of Mechanical Turk (MTurk), 70% of people believed the scientific consensus about the virus originating in animals and rejected related conspiracy theories….
Neutralization of N501Y Mutant SARS-CoV-2 by BNT162b2 Vaccine-Elicited Sera
[pre-print, not peer-reviewed] Sera from people vaccinated with the Pfizer-BioNTech mRNA vaccine (BNT162b2) (n=20) had equivalent neutralizing antibody titers to the SARS-CoV-2 strain on which the vaccine was based and a laboratory-developed SARS-CoV-2 strain carrying a N501Y substitution, which is one of the mutations associated with rapidly spreading variants in the United Kingdom and South…
December 28, 2020
Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers
The presence of SARS-CoV-2 anti-spike or anti-nucleocapsid IgG antibodies was associated with a reduced risk of SARS-CoV-2 reinfection over 6 months of follow-up among health care workers in the UK (n=12,541). The risk of testing positive for SARS-CoV-2 by PCR during study follow-up was 1.09 per 10,000 person-days at risk among workers who were negative…
December 17, 2020
REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19
An interim analysis of the ongoing randomized placebo-controlled phase 1-3 trial of the antibody cocktail REGN-COV2 among non-hospitalized patients with COVID-19 (n=228) found a larger reduction in SARS-CoV-2 viral load among patients in the treatment group vs. the placebo group, with a mean difference of -0.41 log10 copies per milliliter (95% CI, −0.71 to −0.10)….
December 7, 2020
A Prospective Study on Rapidly Declining SARS‐CoV‐2 IgG Antibodies Within One to Three Months of Testing IgG Positive: Can It Lead to Potential Reinfections?
A prospective study of IgG antibody concentrations among 201 individuals in India who tested positive for SARS-CoV-2 found that only 28.4% of participants retained IgG antibody responses at 45-65 days follow-up. The authors highlight the need for future studies that use quantitative antibody assays and measure neutralizing antibody to assess risk of reinfection. Nag et…
November 20, 2020
Kinetics and seroprevalence of SARS-CoV-2 antibodies in children
Changes in the concentration of antibodies against SARS-CoV-2 over time in children were found to be similar to adults. In a prospective multicenter cohort study of antibody responses in 849 children, antibody titers in children exposed to SARS-CoV-2 remain at a detectable level for at least 62 days, with the mean titer increasing over time….
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