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Tag: breakthrough infection
June 9, 2021
Outbreak of SARS-CoV-2 B.1.1.7 Lineage after Vaccination in Long-Term Care Facility, Germany, February-March 2021
A SARS-CoV-2 outbreak in a long-term care facility in Germany resulted in a milder disease course, considerably shorter viral RNA shedding (7.5 vs 31 days), and lower peak viral load in vaccinated residents with breakthrough infection compared to unvaccinated residents. The outbreak involved a sequence-confirmed B.1.1.7 (Alpha) variant and resulted in 16 breakthrough infections in…
Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany
In a cohort of elderly residents of an assisted living facility in Germany (n=71, median age 81 years) vaccinated with the Pfizer-BioNTech vaccine only 46% (24 of 52) developed neutralizing antibodies 3 weeks after the first dose and 90% (63 of 70) 4 weeks after the second dose. In contrast, 91% (97 of 107) of…
June 7, 2021
Adverse Outcomes Associated with SARS-CoV-2 Variant B.1.351 Infection in Vaccinated Residents of a Long Term Care Home, Ontario, Canada
Over a period of 3 weeks, an outbreak at a long-term care facility in Ontario, Canada likely originating from an unvaccinated staff member infected with the B.1.351 variant sickened 4 staff members (2 fully vaccinated, 1 single dose, one unvaccinated) and 9 fully vaccinated residents. Two unvaccinated staff members had infections due to other variants…
Effectiveness of MRNA COVID-19 Vaccines among Employees in an American Healthcare System
[Pre-print, not peer-reviewed] A study of SARS-CoV-2 infections among employees of the Cleveland Clinic Health System found that after adjusting for the slope of the epidemic curve, age, and job type, vaccination was associated with a significantly reduced risk of infection (HR = 0.03), corresponding to a vaccine effectiveness of 97.1%. Vaccine effectiveness was 89.2%…