Alliance for Pandemic Preparedness

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Tag: children


April 29, 2021

Detecting In-School Transmission of SARS-CoV-2 from Case Ratios and Documented Clusters

[Pre-print, not peer-reviewed] A SARS-CoV-2 transmission model that accounts for a lower probability of symptomatic infection among children (21%) than adults (70%) found that only roughly 4% of in-school child-to-child transmission would be detectable with symptom-based contact tracing, even if all symptomatic cases are detected. The authors suggest that low in-school detection rates do not…


April 27, 2021

Risk Factors for Long Covid in Previously Hospitalised Children Using the ISARIC Global Follow-up Protocol A Prospective Cohort Study

[Pre-print, not peer-reviewed] 24% of children hospitalized with COVID-19 in Moscow, Russia reported persistent symptoms at approximately 1 year post-discharge (n=518; median age 10 years). The most commonly reported symptoms were fatigue, followed by sleep disturbance and sensory problems. Persistent symptoms were more common among those aged 6-18 years compared to patients aged <2 years,…


Comparison of COVID-19 Incidence Rates Before and After School Reopening in Israel

An analysis of SARS-CoV incidence and the rate of test positivity in Israel suggests that children age 0-9 years of age did not have substantially elevated rates of SARS-CoV-2 infection during school attendance. Compared to the period before school reopening, after school reopened in September 2020 there was a 10% increase in SARS-CoV-2 incidence and…


April 26, 2021

Simulated Identification of Silent COVID-19 Infections Among Children and Estimated Future Infection Rates With Vaccination

A modeling study determined that, in the absence of SARS-CoV-2 vaccines available to children, identifying 10-20% of “silent” or asymptomatic infections among children within 3 days after infection would reduce attack rates below 5% if only adults were vaccinated. Using an age-structured disease transmission model parameterized with census data, the study also found that if…


April 22, 2021

Hospital Admissions for Abusive Head Trauma at Children’s Hospitals During COVID-19

A retrospective analysis determined that the rate of abusive head trauma (AHT) had decreased substantially among children during the pandemic. AHT was used as a surrogate for child abuse, as the authors hypothesized that it would be more difficult for caregivers to forgo care than for non-life-threatening abuse. Mean monthly hospital admissions for AHT across…


April 21, 2021

Post-Acute COVID-19 Outcomes in Children with Mild and Asymptomatic Disease

A multicenter cohort study across Europe conducted among children ≤18 years diagnosed with SARS-CoV-2 infection at a tertiary care hospital found that significant risk factors for ICU admission were age <1 month (OR = 5.1), male sex (OR = 2.1), pre-existing medical conditions (OR = 3.3), and presence of lower respiratory tract infection signs or…


April 13, 2021

A Public Health Antibody Screening Indicates a Marked Increase of SARS-CoV-2 Exposure Rate in Children during the Second Wave

SARS-CoV-2 seroprevalence among children aged 1-10 years in Bavaria, Germany increased from 0.68% during the first wave (January-August 2020) to 3.92% during the second wave (September-February 2021). The authors suggest that the increase in seropositivity was likely caused by generally higher virus exposure during fall and winter, school openings, and the introduction of variants. By…


April 12, 2021

Infectivity of Severe Acute Respiratory Syndrome Coronavirus 2 in Children Compared with Adults

Compared with adults, children with SARS-CoV-2 positive nasopharyngeal swabs (NPS) were less likely to grow virus in culture (OR=0.45) and had lower viral concentrations (cycle threshold: 25.1 age≤ 10 years, 22.2 age 11–17 years, and 18.7 in adults), suggesting that children may be less likely to transmit infectious virus. The analysis included samples from children…


March 23, 2021

Details of COVID-19 Disease Mitigation Strategies in 17 K-12 Schools in Wood County Wisconsin

[Pre-print, not peer-reviewed] Minimal in-school transmission of COVID-19 occurred despite low adherence to mitigation measures and minimal improvements in ventilation systems between August and November 2020 in Wood County, Wisconsin. According to surveys distributed to the administrations of participating schools, 89% of elementary students did not maintain 6 feet of physical distancing in the classroom,…


March 15, 2021

Household SARS-CoV-2 Transmission and Children: A Network Prospective Study

A study of SARS-CoV-2 household transmission in Spain found that while viral transmission was common among household members (62.3%), among the 1,040 children under age 16 included in the study, more than 70% (756) of cases were acquired from an adult, whereas only 7.7% (80) were index cases. Almost half (47.2%) were asymptomatic, 10.8% had…



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