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Tag: clinical characteristics
January 27, 2021
Association of Psychiatric Disorders With Mortality Among Patients With COVID-19
Diagnosis of a schizophrenia spectrum disorder was significantly associated with increased risk of 45-day mortality among adults who tested positive for SARS-CoV-2, after adjusting for demographic and medical risk factors (OR=2.7). The retrospective cohort study enrolled 7,348 individuals at a large medical system in New York, 75 (1%) of whom had a history of a…
January 25, 2021
NERVTAG Note on B.1.1.7 Severity
[Report, not peer-reviewed] The UK New and Emerging Respiratory Virus Advisory Group (NERVTAG) states the B.1.1.7 SARS-CoV-2 variant has quickly become dominant in the UK, and that there is a possibility that infection with this variant is associated with increased risk of death compared to previous strains. NERVTAG cites evidence of increased case fatality from…
January 22, 2021
Neurological Complications of COVID‐19 in Hospitalized Patients: The Registry of a Neurology Department in the First Wave of the Pandemic
A hospital-based registry found a low prevalence of neurological complications in patients hospitalized for COVID‐19. Among 2,750 people hospitalized for COVID-19 in a single hospital in Spain, 71 (3%) experienced at least one neurological complication within four months of follow-up. The most common diagnoses were neuromuscular disorders (34%), cerebrovascular diseases (27%), acute encephalopathy (19%), and…
Demographic Predictors of Hospitalization and Mortality in US Children with COVID-19
Although deaths and hospitalizations are rare among children in the United States diagnosed with COVID-19, Black and multiracial children are more likely than white children to be hospitalized (OR=1.5) and die (OR=3.0). Children with a prior medical condition are also more likely to be hospitalized (OR=3.6) and to die (OR=8.8). Of the 27,045 children whose…
January 21, 2021
Clinical and Laboratory Features of Hypercoagulability in COVID-19 and Other Respiratory Viral Infections amongst Predominantly Younger Adults with Few Comorbidities
A retrospective cohort study among hospitalized COVID-19 patients (n=181) and patients with other respiratory viral infections (n=165) found similarly low rates of arterial or venous thrombotic events. However, clot waveform analysis parameters were significantly higher among severe than mild COVID-19 patients, suggesting increased risk for hypercoagulability. Patients in the ICU routinely received the thrombosis prevention…
January 15, 2021
Circulating Mitochondrial DNA Is an Early Indicator of Severe Illness and Mortality from COVID-19
Elevated mitochondrial DNA levels measured within 24 hours of presentation were associated with mortality, ICU admission, intubation, vasopressor use, and renal replacement therapy in patients hospitalized with COVID-19. These associations were maintained after adjustment for age, sex, and comorbidities. Circulating mitochondrial DNA levels demonstrate similar or improved sensitivity over clinically established measurements for assessing potential…
Clinical Characteristics and Outcomes of Hospitalized Women Giving Birth With and Without COVID-19
Women hospitalized for childbirth with confirmed COVID-19 (n=6,380) were younger, more often Black and/or Hispanic, and more often had diabetes or obesity than women without COVID-19. Although in-hospital mortality was low, it was significantly higher in the women with COVID-19 than in those without COVID-19 (141 vs 5 deaths per 100,000 women). The women with…
The Epidemiological and Radiographical Characteristics of Asymptomatic Infections with the Novel Coronavirus (COVID-19): A Systematic Review and Meta-Analysis
A systematic review and meta-analysis (104 studies, n=20,152 participants) found that 13.3% of individuals with SARS-CoV-2 infection were asymptomatic, though there was substantial variation between studies (I2=95%). Children were more likely to be asymptomatic than adults (32% vs. 10%). More than 47% of asymptomatic individuals who had chest imaging had abnormal lung findings. Chen et…
January 14, 2021
Testing, Infection and Complication Rates of COVID-19 among People with a Recent History of Homelessness in Ontario, Canada: A Retrospective Cohort Study
A population-based retrospective cohort study in Ontario, Canada (n=29,407) found that compared to community-dwelling people, people with a recent history of homelessness were more likely to be tested for SARS-CoV-2 and to have a positive test result during the pre-shutdown, peak, and reopening phases of the pandemic. During the peak period, people with a recent…
January 13, 2021
Epidemiology of COVID-19 in Mexico, Symptomatic Profiles and Presymptomatic People
Epidemiologic data collected between June and September 2020 from more than 480,000 outpatients with RT-PCR-confirmed SARS-CoV-2 infection in Mexico indicated that there was a high incidence of COVID-19 among working-age people (41%), with young adults (aged 20-40 years) the most affected. More than half of the people who tested positive (53%) had contact with SARS-CoV-2…
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