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Tag: clinical characteristics
January 13, 2021
Diarrhea Is Associated with Increased Severity of Disease in COVID-19: Systemic Review and Meta-analysis
A systematic review and meta-analysis (n = 38 studies, 8,407 patients) of COVID-19 gastrointestinal symptoms found that 16% of all patients had at least one GI symptom. The pooled prevalence of nausea/vomiting was 8% and diarrhea was 12%. Patients with diarrhea as one of their presenting symptoms were more likely to have severe disease (OR=1.63)….
Clinical Outcomes and Inflammatory Markers by HIV Serostatus and Viral Suppression in a Large Cohort of Patients Hospitalized With COVID-19
A retrospective cohort study of 4,613 patients positive for SARS-CoV-2 admitted to a hospital in New York City between March 10 and May 11, 2020 found that people living with HIV had increased risk of intubation (aHR=1.73) but similar rates of acute kidney injury and in-hospital death as those without HIV. Most patients were either…
January 11, 2021
The Importance of Anosmia, Ageusia and Age in Community Presentation of Symptomatic and Asymptomatic SARS-CoV-2 Infection in Louisiana, USA; a Cross-Sectional Prevalence Study
A cross-sectional SARS-CoV-2 seroprevalence study in Louisiana found that reported loss of taste or smell was strongly associated with a positive (PCR or antibody) test (OR: 13.6). Among people who tested positive, 47.3% (147/311) were asymptomatic. Modeling the probability of symptoms showed that the highest probability of reporting symptoms was 64.6% at age 29, which…
Prevalence and Clinical Significance of Persistent Viral Shedding in Hospitalized Adult Patients with SARS-CoV-2 Infection: A Prospective Observational Study
A prospective observational study of adults hospitalized with SARS-CoV-2 infection (n=121) detected persistent viral shedding (PVS) for at least 21 days in up to 38% of patients, which was strongly associated with immunosuppression (6.7% vs 21.7%), increased IL-6 levels (43.4% vs 67.3%), and need for mechanical ventilation (20.0% vs 41.3%). Time from onset of symptoms…
6-Month Consequences of COVID-19 in Patients Discharged from Hospital: A Cohort Study
A cohort study following patients recovering from COVID-19 in Wuhan, China found that fatigue or muscle weakness (63%) and sleep difficulties (26%) were the most commonly reported symptoms during the 6 months post-discharge. Anxiety or depression was reported among 23% of patients. In a comparison of laboratory values during the acute phase of illness versus…
January 8, 2021
Candida Auris Outbreak in a COVID-19 Specialty Care Unit — Florida, July–August 2020
A dedicated COVID-19 specialty care unit at an acute care hospital in Florida reported four fungal infections with Candida auris, which is often resistant to several anti-fungal medications, in July 2020. An additional 35 patients were found to be colonized with C. auris during testing between August 4 and 18. During that time, investigators observed…
January 7, 2021
Outcomes of COVID-19 in Hospitalized Solid Organ Transplant Recipients Compared to a Matched Cohort of Non-Transplant Patients at a National Healthcare System in the United States
Solid organ transplant (SOT) recipients with COVID-19 were more likely to experience adverse outcomes than matched non-SOT recipients in a cohort study conducted between March and September 2020. SOT recipients (n=128) were 1.9 times more likely to die within the study period compared to non-SOT patients (n=3,907). SOT recipients were also more than twice as…
Insight into the Reason of Prolonged Viral RNA Shedding in Patients with COVID-19 Infection
A cohort study (n=681) in Italy found that older age was independently associated with prolonged viral shedding. Patients who first had two consecutive negative nasopharyngeal swabs 1-2 days apart within <3 weeks, 3-6 weeks, and >6 weeks, had a mean age of 50.5 years, 57 years, and 65.8 years, respectively (p<0.05). Bongiovanni et al. (Jan…
January 6, 2021
Saliva Viral Load Is a Dynamic Unifying Correlate of COVID-19 Severity and Mortality
[Pre-print, not-peer reviewed] In a cohort of 154 hospitalized patients, salivary viral load showed a superior ability over nasopharyngeal viral load to predict mortality over time (AUC=0.90). Salivary viral load was positively associated with COVID-19 inflammatory markers and type 1 immune response cytokines and higher viral loads strongly correlated with depletion of platelets, lymphocytes, and…
January 4, 2021
Racial Disparities in COVID-19 Hospitalizations Do Not Lead to Disparities in Outcomes
A retrospective study of 799 patients hospitalized with COVID-19 in Michigan showed that while Black patients had disproportionately higher rates of hospitalization, mortality was not higher in Black patients in multivariate analysis (aOR=0.61). Black patients tended to be younger (62.9 years vs. 71.8), had a higher mean body mass index (32.4 kg/m2 vs 28.8), had higher prevalence…
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