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Tag: clinical characteristics
June 9, 2021
Risk Factors Associated With COVID-19 Outcomes Among People With Intellectual and Developmental Disabilities Receiving Residential Services
In adults with intellectual and developmental disabilities (IDD) receiving residential services in New York City (n=543), age and pre-existing conditions, such chronic kidney disease, were associated with a COVID-19 diagnosis. These risk factors were similar to those reported in the general population. Diagnosis of Down syndrome was also associated with a COVID-19 diagnosis (OR=3), while…
June 8, 2021
Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children
29% of pediatric US COVID-19 patients aged ≤18 years (n=43,465) had at least one underlying medical condition, according to an analysis of data collected from more than 800 US hospitals from March 2020 to January 2021. The most common diagnosed conditions were asthma (10%), neurodevelopmental disorders (4%), anxiety and fear-related disorders (3%), depressive disorders (3%),…
Long-COVID Following Mild SARS CoV-2 Infection Characteristic T Cell Alterations and Response to Antihistamines
[Pre-print, not peer-reviewed] “Long COVID” patients with persistent symptoms (mean symptom duration 269 days) treated with histamine receptor antagonists (HRA) (n=25) reported an average reduction in symptom burden by 60%. 20% reported complete symptom resolution, 52% experienced some improvement, and 6 reported no change with a mean time to response of 30 days. By contrast,…
June 7, 2021
The Role of HIV Infection in the Clinical Spectrum of COVID-19 a Population-Based Cohort Analysis Based on US National COVID Cohort Collaborative (N3C) Enclave Data
[Pre-print, not peer-reviewed] A study using electronic health record data from 54 clinical sites in the National COVID Cohort Collaborative found that people living with HIV (PLWH, n=13,170) had a higher risk of COVID-19 death and hospitalization after adjusting for age and sex. The associations were attenuated, but remained significant, after adjusting for smoking status,…
Plasma ACE2 Predicts Outcome of COVID-19 in Hospitalized Patients
Among patients with COVID-19 (n=306), high plasma levels of angiotensin converting enzyme 2 (ACE2) at hospital admission were associated with increased illness severity within 28 days (OR = 1.8), and plasma ACE2 was significantly higher among patients with hypertension. Circulating ACE2 was also significantly higher in patients with COVID-19 with pre-existing heart conditions and kidney…
June 4, 2021
Variant-of-Concern-Attributable Health and Health System-Related Outcomes a Population-Level Propensity-Score Matched Cohort Study
[Pre-print, not peer-reviewed] A population-based propensity-score matched cohort study of all incident laboratory-confirmed COVID-19 cases in Ontario, Canada found that SARS-CoV-2 variants of concern are associated with a higher odds of hospitalization (OR=2.3), ICU admission (OR=3.3), and mortality among persons hospitalized (OR=1.6) and not hospitalized (OR=1.8) for COVID-19 relative to earlier wild-type strains. The findings…
Immunological Dysfunction Persists for 8 Months Following Initial Mild-Moderate SARS-CoV-2 Infection
[Pre-print, not peer-reviewed] A prospective cohort study found that persons with persistent symptoms following COVID-19 infection had an elevated diffuse inflammatory cytokine profile at 8 months post SARS-CoV-2 infection, which was not observed in age/gender matched asymptomatic COVID-19 survivors, healthy controls, or persons who survived other human coronaviruses. Additionally, persons with persisting symptoms had a…
Hospitalization of Adolescents Aged 12–17 Years with Laboratory-Confirmed COVID-19 — COVID-NET, 14 States, March 1, 2020–April 24, 2021
A review of COVID-19 associated hospitalizations among adolescents aged 12-17 years (N=204) found that the rate of hospitalization peaked at 2.1 per 100,000 in early January 2021, declined to 0.6 in mid-March, and rose to 1.3 in April. Among hospitalized adolescents, nearly 1 in 3 required ICU admission, 5% required invasive mechanical ventilation, and no…
June 3, 2021
Co-Infections, Secondary Infections, and Antimicrobial Use in Patients Hospitalised with COVID-19 during the First Pandemic Wave from the ISARIC WHO CCP-UK Study: A Multicentre, Prospective Cohort Study
Of 1,080 microbiologically confirmed infections in patients hospitalized for COVID-19 between February and June 2020 in the UK, 762 (70.6%) were secondary, occurring >2 days after hospital admission. Among patients hospitalized for COVID-19 during this period and with available data, 37% (13,390 of 36,1456) had received antimicrobials in the community prior to hospital admission, and…
Carbapenem-Resistant Klebsiella Pneumoniae Infections in ICU COVID-19 Patients—A Scoping Review
A literature review including 10 studies found evidence of hospital-based infection caused by the bacterium Klebsiella pneumoniae that was resistant to the carbapenem class of antibiotics among ICU patients with COVID-19 in 6 countries, ranging in prevalence from 0.35% to 53%. The majority of infected patients were male (85%), with a mean age of 61…
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