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Tag: clinical characteristics
October 19, 2020
Cardiovascular Diseases Burden in COVID-19: Systematic Review and Meta-Analysis
A systematic review and meta-analysis of cardiovascular disease (CVD) and COVID-19 (n=56 studies) identified a high burden of CVD among individuals with COVID-19 and significantly elevated risk for mortality and ICU admission among COVID-19 patients with CVD. Specifically, acute cardiac injury, (OR=13.3), hypertension (OR=2.6), heart failure (OR=6.7), arrhythmia (OR=2.8), coronary artery disease (OR=3.8), and cardiovascular…
Cytokine Elevation in Severe and Critical COVID-19: A Rapid Systematic Review, Meta-Analysis, and Comparison with Other Inflammatory Syndromes
Mean interleukin (IL)-6 concentrations among patients with severe COVID-19 were significantly lower than concentrations found among patients with other critical illnesses associated with elevated cytokine concentrations. A systematic review and meta-analysis compared COVID-19 studies in which IL-6 concentrations in patients with severe or critical disease were recorded with studies of sepsis, cytokine release syndrome, and…
October 16, 2020
Decreasing Median Age of COVID-19 Cases in the United States—Changing Epidemiology or Changing Surveillance?
A retrospective review of SARS-CoV-2-positive molecular testing results in the US between early (March-April 2020) and later periods (June-July 2020) found a trend toward decreasing age among people with laboratory-confirmed SARS-CoV-2 infection, but that these trends seem to be specific to the outpatient population. In the early period, the median age of individuals testing positive…
October 15, 2020
Clinical Characteristics Symptoms Management and Health Outcomes in 8598 Pregnant Women Diagnosed with COVID-19 Compared to 27510 with Seasonal Influenza in France Spain and the US
[Pre-print, not peer reviewed] A network cohort analysis of 8,598 pregnant women from France, Spain, and the US with COVID-19 found that women who were eventually hospitalized were more likely to have kidney impairment and anemia. Compared to a cohort of 27,510 pregnant women diagnosed with influenza during the 2017-2018 flu season, pregnant women with…
October 12, 2020
COVID-19 and Excess All-Cause Mortality in the US and 18 Comparison Countries
The cumulative COVID-19 mortality in the US through September 19, 2020 of 60.3 per 100,000 people is comparable to other high-mortality countries like Spain (65 per 100,000), the UK (62.6 per 100,000) and Italy (59.1 per 100,000). However, the COVID-19 mortality in the US has remained high in the past four months, while the other…
Excess Deaths From COVID-19 and Other Causes, March-July 2020
Deaths from all causes in the US increased by 20% above the number expected between March 1 and August 1, 2020. An estimated 150,541 of these excess deaths (67%) were attributed to COVID-19. The 10 states with the highest per capita level of excess deaths were New York, New Jersey, Massachusetts, Louisiana, Arizona, Mississippi, Maryland,…
October 9, 2020
Neuropathology of Patients with COVID-19 in Germany: A Post-Mortem Case Series
A study of brain tissue from patients who died from COVID-19 indicated that 79% had pronounced neuroinflammatory changes in the brainstem and cerebellum, though in general, neuropathological changes seemed to be mild in most patients. SARS-CoV-2 was detected in 53% of the patients’ brains, and the study found no evidence for central nervous system damage…
Prevalence and Outcome of COVID-19 Infection in Cancer Patients: A National Veterans Affairs Study
The pre-existence of cancer may affects both susceptibility to COVID-19 infection and outcomes, according to an analysis of healthcare records from the US Veterans Affairs healthcare system. The overall COVID-19 attributable mortality in patients with cancer was 10%, which was higher with older age, a higher Charlson comorbidity score, and certain types of cancer. The…
Follow-up of Adults with Non-Critical COVID-19 Two Months after Symptoms’ Onset
Two-thirds of adults with non-critical COVID-19 experienced persisting symptoms up to 2 months after initial onset, with symptoms including loss of taste or smell, difficulty breathing, and fatigue. In an observational study of 150 patients with mild or moderate COVID-19, persisting symptoms at 60 days were significantly more common among those age 40 to 60…
Characteristics of Hospitalized Children With SARS-CoV-2 in the New York City Metropolitan Area
Children with comorbidities who were hospitalized with SARS-CoV-2 were at increased risk for critical care admission and/or need for respiratory support, based on results from a multicenter, retrospective cohort study at four hospitals in the New York City metropolitan area. Obesity was the most commonly observed risk factor for critical care (63% vs. 28%), while…
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