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Tag: clinical characteristics
October 6, 2020
A Prospective Study of Neurologic Disorders in Hospitalized COVID-19 Patients in New York City
A prospective multi-center observational study of hospitalized COVID-19 patients in New York City (n=4,491) found that 14% of patients developed a new neurological disorder at a median of 2 days after COVID-19 symptom onset, which was also associated with increased adjusted risk of in-hospital mortality and decreased likelihood of hospital discharge. The most common diagnoses…
October 5, 2020
Patient-Reported Outcome Measures after COVID-19: A Prospective Cohort Study
Among 78 patients who were hospitalized with COVID-19 from March to June 2020 in Vancouver, Canada, 76% reported having at least one lingering health effect 3 months after symptom onset and 56% reported at least 2 health effects. The most frequently reported complaints were lower quality of life (51%) and shortness of breath (50%). Wong…
Frequent Neurologic Manifestations and Encephalopathy-Associated Morbidity in Covid-19 Patients
One third (162/509) of patients hospitalized with COVID-19 in the Chicago area experienced some type of altered mental function, ranging from confusion to delirium to unresponsiveness. These patients stayed three times as long in the hospital as patients without altered mental function, indicating patients with encephalopathy may have poorer outcomes and need closer post-discharge monitoring…
October 2, 2020
Clinical Characteristics of Asymptomatic Patients with SARS-CoV-2 in Zhejiang: An Imperceptible Source of Infection
A retrospective study of 22 asymptomatic patients infected with SARS-CoV-2 and 234 symptomatic patients with COVID-19 who were hospitalized in Hangzhou, China found that asymptomatic patients tended to be younger (28 years vs. 48 years), female (77% vs 36%), and had fewer coexisting diseases (5% vs 38%) than symptomatic patients. Dai et al. (Sept 19,…
Sequelae of COVID-19 in Hospitalized Children
A study of 28 hospitalized pediatric patients with COVID-19 in Turin, Italy found that all participants had nasal swabs negative for SARS-CoV-2 by PCR one month after discharge. Lung ultrasound findings had normalized within 5 weeks from hospital discharge in the majority of patients. 20 out of 24 patients developed anti-SARS-CoV-2 IgG at the follow-up…
Symptom Characterization and Outcomes of Sailors in Isolation After a COVID-19 Outbreak on a US Aircraft Carrier
Among sailors who disembarked from the USS Theodore Roosevelt, 736 out of 4,085 (18%) were positive for SARS-CoV-2, of whom 590 (80%) were symptomatic. Six sailors were hospitalized and one died. Loss of taste and smell were reported commonly. The authors note that in confined areas with young essential workers, COVID-19 symptoms may not be…
Case Series of Multisystem Inflammatory Syndrome in Adults Associated with SARS-CoV-2 Infection — United Kingdom and United States, March – August 2020
Morris et al. report 27 cases of multisystem inflammatory syndrome (MIS) associated with SARS-CoV-2 infection in adults that have been reported to CDC or published in the literature. MIS has been previously described among children and adolescents. MIS differs from typical manifestations of severe COVID-19 in that patients with MIS have minimal respiratory symptoms, hypoxemia,…
October 1, 2020
Expression of SARS-CoV-2 Entry Receptors in the Respiratory Tract of Healthy Individuals, Smokers and Asthmatics
Using publicly available microarray datasets, Matusiak and Schürch reported different protein expression of SARS-CoV-2 entry receptors and cofactors ACE2, TMPRSS2, BSG (CD147) and FURIN among various airway tissue types between smokers vs. non-smokers, and between people with asthma vs. healthy controls. These findings warrant further studies to use larger numbers of samples from multiple donor cohorts and more antibodies…
The Obesity Paradox: Analysis from the SMAtteo Covid-19 REgistry (SMACORE) Cohort
Obesity (BMI ≥30 kg/m2) was associated with a higher risk of ICU admission (adjusted OR=1.96, 95%CI 1.03-3.75) among a cohort of 331 patients hospitalized with COVID-19 at the beginning of the epidemic in Italy. There were no significant differences in mortality, mortality in ICU and length of hospital stay between obese patients and non-obese patients….
September 30, 2020
Association of a Prior Psychiatric Diagnosis With Mortality Among Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) Infection
Among a cohort of hospitalized patients with COVID-19 in the US (n=1685), the risk of death remained significantly greater among patients with a psychiatric disorder after controlling for demographic characteristics, other medical comorbidities, and hospital location. Li et al. (Sept 30, 2020). Association of a Prior Psychiatric Diagnosis With Mortality Among Hospitalized Patients With Coronavirus…
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