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Tag: clinical characteristics
May 26, 2021
Estimating Infectiousness throughout SARS-CoV-2 Infection Course
An analysis of 936,423 SARS-CoV-2 RT-PCR-positive samples from hospitalized and non-hospitalized persons in Germany found that high viral loads (> 109 copies per swab) were found in 8% of subjects, 1/3 of whom were pre-symptomatic, asymptomatic, or mildly symptomatic. The mean number of days from onset of viral shedding to peak viral load was 4.3….
May 25, 2021
Poor Nutritional Status, Risk of Sarcopenia and Nutrition Related Complaints Are Prevalent in COVID-19 Patients during and after Hospital Admission
73% of patients hospitalized for COVID-19 were at high risk of muscle tissue loss (sarcopenia) and 22% of patients experienced serious acute weight loss (>5kg), according to a prospective observational cohort in the Netherlands conducted from April to December 2020 (n=407). Muscle tissue loss was defined as ≥4 points on the SARC-F questionnaire during hospitalization….
Post-COVID Syndrome in Non-Hospitalised Patients with COVID-19: A Longitudinal Prospective Cohort Study
Shortness of breath, fatigue, loss of smell, and loss of taste persisted in 9%, 10%, 12%, and 11%, respectively, in a cohort of 442 individuals with COVID-19 (mostly mild cases) who were followed up at 4 months post-infection in Germany. At least one of these characteristic symptoms was present in 123 participants at both the…
May 24, 2021
Maternal and Perinatal Outcomes of Pregnant Women with SARS-CoV-2 Infection at the Time of Birth in England: National Cohort Study
A population-based cohort study of pregnant persons in England (n = 342,080) in the context of universal screening for SARS-CoV-2 at delivery hospitalization found that SARS-CoV-2 infection was more common among those who were younger, of non-white ethnicity, pregnant for the first time, resided in the most deprived areas, or had comorbid conditions. Risk of…
May 21, 2021
Factors Associated with Readmission in the US Following Hospitalization with COVID-19
A retrospective cohort study of persons hospitalized for COVID-19 between February and June 2020 in the US (N=29,659) found that 3.6% were readmitted within 30 days of their initial hospitalization and 12.3% died during their second hospitalization. The rate of readmission was highest within 10 days of discharge from the initial hospitalization. Persons readmitted were…
Risk of Clinical Sequelae after the Acute Phase of SARS-CoV-2 Infection: Retrospective Cohort Study
A large retrospective cohort study of US adults aged 18-65 enrolled in commercial insurance (N=9,247,505) found that 14% of individuals with documented SARS-CoV-2 infection developed at least 1 new clinical sequala requiring medical care after the acute phase of COVID-19 disease. In comparison, 9% of persons without SARS-CoV-2 infection and 13% of persons with a…
May 20, 2021
Population-Based Estimates of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) Prevalence and Characteristics
Persistent COVID-19 symptoms 30 days and 60 days after symptom onset were present in 53% and 35% of participants, respectively, in a population-based survey in Michigan (n=593). Prevalence of 30-day and 60-day symptoms was 40% higher in hospitalized patients than in non-hospitalized patients, while those who reported very severe symptoms (vs mild) had a 2-fold…
Characteristics Associated With Multisystem Inflammatory Syndrome Among Adults With SARS-CoV-2 Infection
In a single-center cohort study of patients hospitalized for acute COVID-19 (n=698), 15 patients were identified with multisystem inflammatory syndrome for adults (MIS-A). The 15 MIS-A patients had acute COVID-19 symptoms, and for MIS-A patients with prior admission for acute COVID-19 (n=3), the median interval between acute COVID-19 admission and MIS-A admission was 23 days….
Assessment of the Association of Vitamin D Level With SARS-CoV-2 Seropositivity Among Working-Age Adults
Low levels of Vitamin D (<20 ng/mL) was not associated with positivity for anti-SARS-CoV-2 IgG antibodies (OR=1.04, 95% CI=0.88-1.22), after adjustment for confounders in a large cohort study of US employees and spouses of Quest Diagnostics (n=18,148). Vitamin D levels were measured prior to the pandemic in 2019 and results were adjusted for age, sex,…
May 19, 2021
Pregnancy and Birth Outcomes after SARS-CoV-2 Vaccination in Pregnancy
[Pre-print, not peer-reviewed] The prevalence of adverse maternal or neonatal outcomes was the same among pregnant women who received a COVID-19 vaccine during pregnancy and unvaccinated pregnant women (5%). Findings are based on an analysis of a delivery cohort (n=2,002) created by matching a delivery database from the Mayo Clinic with a comprehensive vaccine registry….
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