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Tag: clinical characteristics
April 30, 2021
SARS-CoV-2 Seroprevalence, and IgG Concentration and Pseudovirus Neutralising Antibody Titres after Infection, Compared by HIV Status: A Matched Case-Control Observational Study
Persons living with HIV had lower SARS-CoV-2 IgG seroprevalence (3.7%) compared to persons without HIV (7.4%), according to a retrospective matched case-control study (N=2,200) of remnant serum samples from US adults presenting for routine laboratory testing. However, among those who had past SARS-CoV-2 infection, persons living with HIV were more likely to have had severe…
April 28, 2021
Half-year Follow-up of Patients Recovering from Severe COVID-19: Analysis of Symptoms and Their Risk Factors
More than half (55.4%, n = 441) of patients who recovered from severe COVID-19 had persistent symptoms (“sequelae”) at six months follow-up. The most common symptoms were fatigue (25.3%), sleep disorder (23.2%) and shortness of breath (20.4%). Compared to those who had been severely ill (defined as hypoxia without respiratory failure), individuals who had been…
April 27, 2021
Fatigue Symptoms Associated with COVID-19 in Convalescent or Recovered COVID-19 Patients a Systematic Review and Meta-Analysis
[Pre-print, not peer-reviewed] Fatigue was more 3.7-fold as common among patients recovering from COVID-19 compared to healthy controls, according to a systematic review of 39 studies (n=8,825 patients). Over half of hospitalized patients reported symptoms of fatigue up to two months after discharge. Female gender was associated with greater self-reported fatigue and self-report of fatigue…
Risk Factors for Long Covid in Previously Hospitalised Children Using the ISARIC Global Follow-up Protocol A Prospective Cohort Study
[Pre-print, not peer-reviewed] 24% of children hospitalized with COVID-19 in Moscow, Russia reported persistent symptoms at approximately 1 year post-discharge (n=518; median age 10 years). The most commonly reported symptoms were fatigue, followed by sleep disturbance and sensory problems. Persistent symptoms were more common among those aged 6-18 years compared to patients aged <2 years,…
6-Month Follow Up of 8679 Hospitalized COVID-19 Patients in Germany A Nationwide Cohort Study
[Pre-print, not peer-reviewed] 180-day mortality was 30% in a large cohort (n=8,679; median age 72 years) from Germany hospitalized with COVID-19 from February to April 2020. 180-day mortality was 52% among patients aged ≥80 years and 53% for patients who had undergone invasive mechanical ventilation. Coagulopathy, BMI ≥ 40, and age were risk factors for…
Genomic Epidemiology of SARS-CoV-2 Infection During the Initial Pandemic Wave and Association With Disease Severity
The SARS-CoV-2 D614G variant was associated with increased survival in hospitalized patients (86% vs 59% for other identified variants) according to analysis from a repeated cross-sectional study (n=302) of SARS-CoV-2 isolates from the Cleveland Clinic during the first wave of infection (March to April 2020). While 6 different clades were initially identified in the beginning…
Impaired Diffusing Capacity for Carbon Monoxide Is Common in Critically Ill Covid-19 Patients at Four Months Post-Discharge
Impaired lung function was present in 52% of COVID-19 patients four months after discharge from the ICU from March to July 2020 (n=60). The most prevalent impairment was lower than normal diffusing capacity for carbon monoxide (DLCO) (45%). Impaired DLCO was more common among those aged >60 years and those who received invasive mechanical ventilation…
April 22, 2021
Immunogenicity of SARS-CoV-2 Vaccine in Dialysis
[Pre-print, not peer-reviewed] 89% of 186 dialysis patients developed anti-SARS-CoV-2 spike antibodies following two doses of mRNA vaccines (Pfizer-BioNTech and Moderna). Among patients without prior SARS-CoV-2 infection (n=148), the seropositivity rate was 86%. A majority (70%) of seropositive patients had maximum titers for anti-spike IgG antibodies at least 14 days after the second dose. No…
April 21, 2021
COVID-19 Associated Mortality and Cardiovascular Disease Outcomes among US Women Veterans
Mortality risk among women veterans who tested positive for SARS-CoV-2 was 4 times that of women veterans who tested negative (HR = 3.8) but women who tested positive had lower risk of cardiovascular events (OR = 0.8) and developing new heart disease conditions within 60 days (OR = 0.7), according to a retrospective analysis of national…
Clinical and Demographic Risk Factors for COVID-19 during Delivery Hospitalizations in New York City
Only 27.9% (22 of 79) pregnant individuals with COVID admitted to two New York City hospitals had symptoms consistent with COVID between March 22 and April 18, 2020. Patients with COVID-19 were slightly less likely to have a vaginal delivery (55.2 vs. 51.9%) and had a longer postpartum length of stay with cesarean delivery (2.00…
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