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Tag: clinical characteristics
April 21, 2021
Post-Acute COVID-19 Outcomes in Children with Mild and Asymptomatic Disease
A multicenter cohort study across Europe conducted among children ≤18 years diagnosed with SARS-CoV-2 infection at a tertiary care hospital found that significant risk factors for ICU admission were age <1 month (OR = 5.1), male sex (OR = 2.1), pre-existing medical conditions (OR = 3.3), and presence of lower respiratory tract infection signs or…
Post-COVID-19 Syndrome in Outpatients a Cohort Study
[Pre-print, not peer-reviewed] In a prospective cohort of symptomatic outpatients undergoing SARS-CoV-2 PCR testing in Switzerland (n= 507), 53% of patients with SARS-CoV-2 infection reported persistent symptoms between 3 and 10 months after diagnosis compared to 37% of patients who tested negative. About 20% of patients who tested positive consulted a physician for persistent symptoms,…
April 20, 2021
Multisystem Inflammatory Syndrome in Infants <12 Months of Age, United States, May 2020–January 2021
A total of 83 of 85 (98%) of infants aged <12 months with multisystem inflammatory syndrome (MIS-C) tested positive for SARS-CoV-2 by either PCR or serology, according to data from a US surveillance system from May 2020 to January 2021. Rash, diarrhea, and vomiting were the most common reported symptoms and the median time from…
Symptoms, Pulmonary Function and Functional Capacity Four Months after COVID-19
Fatigue and shortness of breath with exertion were present four months after infection in approximately 70% of COVID-19 survivors, according to a prospective study of hospitalized COVID-19 patients in Ottawa, Canada (n=25). Among non-hospitalized survivors (n=38), fatigue and exertional breathlessness persisted in 71% and 55%, respectively. At follow-up, forced vital capacity, total lung capacity, peak…
April 19, 2021
Clinical Characteristics of False Negative SARS-CoV-2 Test Results Amongst Hospitalized Patients
False negative SARS-CoV-2 RT-PCR results, defined as an initial negative test followed by a positive test within seven days, were associated with loss of taste or smell (aOR = 8.4), having a SARS-CoV-2-positive contact (aOR = 10.5), and having an elevated lactate dehydrogenase level (aOR = 3.3) compared to true negative results. Among 1,009 SARS-CoV-2 test…
April 16, 2021
SARS-CoV-2 Seropositivity and Subsequent Infection Risk in Healthy Young Adults: A Prospective Cohort Study
US Marine recruits who were seropositive for SARS-CoV-2 antibodies at baseline were 82% less likely than seronegative individuals to have a PCR-confirmed SARS-CoV-2 infection during a 6-week long cohort study. The study population consisted of predominantly male US Marine recruits aged 18-20 years (n=3,076). At baseline, all participants were PCR-negative. During the study period, 19…
April 15, 2021
Mother–Infant Dyads with COVID-19 at an Urban, Safety-Net Hospital: Clinical Manifestations and Birth Outcomes
Seven percent (5 of 75) infants born to women with a positive SARS-CoV-2 PCR test at any stage of gestation until 72 hours after birth had at least one positive PCR test during the first week of life, in an urban safety-net hospital in Boston. All infants had clinical courses expected for their gestational age. Sabharwal…
April 14, 2021
Post-Acute COVID-19 Sequelae in Cases Managed in the Community or Hospital in the UK a Population Based Study
[Pre-print, not peer-reviewed] A population-based study of post-COVID-19 sequelae in England found that hospitalized patients had higher rates of 13 of 26 symptoms assessed and 11 of 19 diseases, and had higher healthcare utilization, than those who had not been hospitalized. Comparing symptom rates (per 100,000 person-weeks), hospitalized patients experienced more breathlessness (536 vs. 87),…
April 12, 2021
Prevalence and Persistent Shedding of Fecal SARS-CoV-2 RNA in Patients With COVID-19 Infection: A Systematic Review and Meta-Analysis
A systematic review and meta-analysis (n = 35 studies) found that the pooled prevalence of SARS-CoV-2 RNA in fecal samples from COVID-19 patients was 43%, and that a higher proportion of patients with gastrointestinal (GI) symptoms (OR = 2.4) compared with no GI symptoms, specifically diarrhea (OR = 3.0), had detectable fecal RNA. SARS-CoV-2 RNA…
April 9, 2021
Neonatal Outcomes during the COVID-19 Pandemic in New York City
A single-center study of singleton births to mothers without SARS-CoV-2 infection who were residents of New York City (N=43,963) found that changes in the rate of preterm births and neonatal intensive care unit (NICU) admissions in the 3 months before and after the stay-at-home orders in response to the COVID-19 pandemic were issued were not…
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