Alliance for Pandemic Preparedness

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Tag: infants

June 15, 2021

Young Infants Exhibit Robust Functional Antibody Responses and Restrained IFN-γ Production to SARS-CoV-2

A study evaluating the immune responses in four infants with mild COVID-19 (median age 7 weeks old) found that compared to their parents who also had COVID-19 (n=8) and a cohort of adult controls with prior COVID-19 (n=10), infants had higher anti-SARS-CoV-2 IgG antibody levels in both sera and saliva and exhibited more robust serum…

May 13, 2021

Perinatal Outcomes During the COVID-19 Pandemic in Ontario, Canada

There were no differences observed in the frequency of preterm birth (7.5%) and stillbirth (0.5%) between a cohort of births during the COVID-19 pandemic (n=67,747) occurring between March and September 2020 and a cohort of pre-pandemic births (n=348,633) occurring within the same calendar period between 2015 and 2019 according to administrative data in Ontario, Canada. …

April 29, 2021

Antibody Response to Coronavirus Disease 2019 (COVID-19) Messenger RNA Vaccination in Pregnant Women and Transplacental Passage Into Cord Blood

Among 122 pregnant women who delivered on or after 35 weeks gestation and received a COVID-19 mRNA vaccine by the time of delivery (n= 55 first dose, n=67 both doses), anti-SARS-CoV-2 IgG antibodies were detected in maternal blood as early as 5 days and in cord blood as early as 16 days after the first…

April 13, 2021

SARS-CoV-2–Specific Antibodies in Breast Milk After COVID-19 Vaccination of Breastfeeding Women

Vaccine-induced SARS-CoV-2-specific antibodies were found in a high proportion of breastmilk samples obtained up to 6 weeks post-vaccination from breastfeeding women in a cohort study in Israel (n=84,504 total samples). IgA antibody positivity peaked at 86% of samples at week 4 (1 week after second dose) and remained at 66% by week 6. IgG antibody…