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Tag: pregnancy
April 29, 2021
Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes
SARS-CoV-2 infection in pregnancy (from conception to 1 week after birth) was significantly associated with a 1.4-fold higher risk of any neonatal respiratory disorder after matching for maternal characteristics in a nationwide cohort study in Sweden (n=88,159 infants). Admission for neonatal care, respiratory distress syndrome, and hyperbilirubinemia were also associated with maternal SARS-CoV-2 test positivity….
Antibody Response to Coronavirus Disease 2019 (COVID-19) Messenger RNA Vaccination in Pregnant Women and Transplacental Passage Into Cord Blood
Among 122 pregnant women who delivered on or after 35 weeks gestation and received a COVID-19 mRNA vaccine by the time of delivery (n= 55 first dose, n=67 both doses), anti-SARS-CoV-2 IgG antibodies were detected in maternal blood as early as 5 days and in cord blood as early as 16 days after the first…
Maternal Antibody Response, Neutralizing Potency, and Placental Antibody Transfer After Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) Infection
Among maternal blood samples from SARS-CoV-2 positive patients obtained after delivery (n=32), higher median anti-RBD IgG titers were significantly associated with symptomatic (vs. asymptomatic) infection but not with having a PCR-positive test more than 14 days earlier (vs. PCR-positive test within 14 days). Paired cord blood samples also obtained after delivery show that median cord/maternal…
April 26, 2021
Association of Maternal Perinatal SARS-CoV-2 Infection With Neonatal Outcomes During the COVID-19 Pandemic in Massachusetts
Five of 255 neonates (2.2%) born to women who tested positive for SARS-CoV-2 within 2 weeks before and 72 hours after delivery also tested positive for SARS-CoV-2 (88% of newborns were tested). A positive neonatal test was associated with higher maternal social vulnerability (aOR = 5.0). Adverse outcomes during hospitalization were associated with preterm delivery…
April 22, 2021
Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study
In an international cohort study, pregnant women with COVID-19 (n=706) were at increased risk for preeclampsia/eclampsia, severe infections, ICU admissions, preterm birth, severe neonatal morbidity and severe perinatal morbidity and mortality compared to those without a COVID-19 diagnosis (n=1,424). Asymptomatic SARS-CoV-2 infection was only associated with increased risk for maternal morbidity and preeclampsia. 13% of…
Preliminary Findings of MRNA Covid-19 Vaccine Safety in Pregnant Persons
Among women in the V-safe pregnancy registry who reported completing pregnancy after receiving COVID-19 mRNA vaccines (Pfizer-BioNTech or Moderna) from December to February 201 (n=827), adverse pregnancy and neonatal outcomes occurred in similar proportions as previously studies of pregnant women conducted before the COVID-19 pandemic. 14% resulted in pregnancy loss, 86% resulted in live birth…
April 20, 2021
Substance Use and Mental Health in Pregnant Women during the COVID-19 Pandemic
Elevated stress, depressive symptoms, and poorer mental/emotional health prior the COVID-19 pandemic were significantly associated with substance abuse during the pandemic, according to a cross-sectional online survey (n=83) conducted in April 2020. Smith et al. (Apr 17, 2021). Substance Use and Mental Health in Pregnant Women during the COVID-19 Pandemic. Journal of Reproductive and Infant Psychology….
April 16, 2021
Effect of SARS-CoV-2 Infection on Pregnancy Outcomes in an Inner-City Black Patient Population
No statistical differences in obstetric or neonatal outcomes were observed between SARS-CoV-2 positive and negative individuals in a cohort study of predominantly Black pregnant women in Brooklyn (n=335). On admission, most (86%) patients who tested positive for SARS-CoV-2 were asymptomatic, and remained asymptomatic throughout their time in the hospital. Rates of preterm birth, cesarean delivery,…
April 15, 2021
Mother–Infant Dyads with COVID-19 at an Urban, Safety-Net Hospital: Clinical Manifestations and Birth Outcomes
Seven percent (5 of 75) infants born to women with a positive SARS-CoV-2 PCR test at any stage of gestation until 72 hours after birth had at least one positive PCR test during the first week of life, in an urban safety-net hospital in Boston. All infants had clinical courses expected for their gestational age. Sabharwal…
April 9, 2021
Neonatal Outcomes during the COVID-19 Pandemic in New York City
A single-center study of singleton births to mothers without SARS-CoV-2 infection who were residents of New York City (N=43,963) found that changes in the rate of preterm births and neonatal intensive care unit (NICU) admissions in the 3 months before and after the stay-at-home orders in response to the COVID-19 pandemic were issued were not…
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