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Tag: pregnancy
December 17, 2020
Inclusion of Pregnant Women in COVID-19 Treatment Trials: A Review and Global Call to Action
A review of COVID-19 treatment trials throughout different timepoints in the pandemic found that a substantial portion of trials listed pregnancy as an exclusion criterion. A review in April found that 80% (124/155) of trials excluded pregnant persons, with a similar finding of 75% (538/722) in July. Among studies focusing on therapeutic drugs (including remdesivir),…
December 8, 2020
Changes in Preterm Birth Phenotypes and Stillbirth at 2 Philadelphia Hospitals During the SARS-CoV-2 Pandemic, March-June 2020
A retrospective study at 2 Philadelphia hospitals did not detect significant changes between pre-pandemic and pandemic rates of adverse birth outcome. The adjusted difference between pre-pandemic and pandemic preterm births and stillbirths were -0.8% and -0.03 per 1,000 births, respectively. Spontaneous preterm birth among non-Hispanic white patients declined during the pandemic (4.5% vs 2.9%), but…
Evaluation of Rooming-in Practice for Neonates Born to Mothers With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Italy
It may be possible to effectively mitigate the risk of mother-to-infant transmission of SARS-CoV-2 infection, based on findings from a multi-cohort study of mother-infant dyads (n=62 neonates, 61 mothers) in Italy that found no positive results among neonates 24 hours after birth despite a 95% breastfeeding rate. Infected mothers observed contact precautions such as handwashing…
December 7, 2020
A Cross-National Study of Factors Associated with Perinatal Mental Health and Wellbeing during the COVID-19 Pandemic
[Pre-print, not peer-reviewed] An anonymous, online, cross-sectional survey of pregnant and postpartum women (n= 6,894) in 64 countries between May and June found that substantial proportions of women scored at or above the cut-offs for elevated posttraumatic stress (43%), anxiety/depression (31%), and loneliness (53%). Excessive information seeking (5 or more times per day from any…
December 1, 2020
Maternal Coronavirus Infections and Neonates Born to Mothers with SARS-CoV-2: A Systematic Review
In a systematic review (n=70 studies) including 1,457 pregnant women with COVID-19, 39 newborns tested positive for SARS-CoV-2. Among mothers, the most frequent comorbidities were obesity, hypertensive disorders, and gestational diabetes. Premature birth (n=64) and maternal death (n=15) were the most common adverse maternal outcomes, while intrauterine fetal distress (n=28) and intrauterine fetal death and…
November 18, 2020
Singleton Preterm Birth Rates for Racial and Ethnic Groups during the Coronavirus Disease 2019 Pandemic in California
In California, the lockdown in response to the COVID-19 pandemic was not associated with changes in the overall rate of pre-term birth (<37 weeks), although there was an increase in the rate of birth at less than 32 weeks. During a 4-month period following the state-wide COVID-19 lockdown in California in March, 2020, there was…
November 16, 2020
Intrauterine Transmission of SARS-CoV-2
A case of fetal death associated with intrauterine transmission of SARS-CoV-2 was documented in Brazil. SARS-CoV-2 RNA was detected in cotyledon samples, membranes, and umbilical cord blood aspirate, suggesting possible breakdown of the placental barrier. However, all fetal tissue samples tested negative. Examination and autopsy found placental lesions and vascular malperfusions, microglial hyperplasia, and lymphocytic…
November 5, 2020
Favorable Outcomes among Neonates Not Separated from Their Symptomatic SARS-CoV-2-Infected Mothers
In France, among 26 SARS-CoV-2 positive mothers and their neonates, nasopharyngeal and anal swabs from neonates at birth, day 3, and weekly if hospital stay was prolonged, only detected one positive PCR test in an anal swab at birth; nasopharyngeal swabs were negative at day 0 and 3. The infant never developed symptoms. None of…
November 2, 2020
Update: Characteristics of Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status — United States, January 22–Oct 3, 2020
Pregnant women with COVID-19 in the US were significantly more likely than nonpregnant women to be admitted to the ICU (aRR = 3.0), receive invasive mechanical ventilation (aRR = 2.9), and to die (aRR = 1.7) after adjusting for age, race/ethnicity, and underlying medical conditions. Although the absolute risks for severe outcomes were low, pregnant…
Birth and Infant Outcomes Following Laboratory-Confirmed SARS-CoV-2 Infection in Pregnancy — SET-NET, 16 Jurisdictions, March 29 – October 14 , 2020
Among infants born to mothers with laboratory-confirmed SARS-CoV-2 infection (n=3,912), 12.9% of live births were preterm (<37 weeks), higher than the reported 10.2% in the general population in 2019. Perinatal infection was infrequent and occurred primarily among infants whose mother had SARS-CoV-2 infection identified within 1 week of delivery. The authors note that since most…
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