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Tag: reinfection
November 23, 2020
Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection After Recovery from Mild Coronavirus Disease 2019
Genetic sequencing among 6 patients who retested positive for SARS-CoV-2 via rRT-PCR after recovery from initial infection identified one reinfection with a subtype of SARS-CoV-2 strain in the spike protein D614G substitution, that was genetically distinct from the initial infection. The positive test with the new strain occurred 26 days after the initial positive test…
November 5, 2020
Clinical Characteristics of Re-Positive COVID-19 Patients in Huangshi, China: A Retrospective Cohort Study
In an observational retrospective cohort study in Huangshi, China, 23 out of 368 recovered COVID-19 patients quarantined for 14 days post-discharge retested positive for SARS-CoV-2. Retesting positivity was associated with a higher ratio of lymphocytes on admission and presence of comorbidities, while negatively associated with a lower peak temperature during hospitalization and arbidol treatment. Zhou…
Clinical Characteristics of Recovered COVID-19 Patients with Re-Detectable Positive RNA Test
Among 262 patients with COVID-19, 14.5% were found to be re-detectable positive (RP) after at least 14 days of follow up. Most RP patients were young (under 60), initially had mild to moderate illness, and had earlier RNA-negative conversion from illness onset (less than 3 weeks) than non-RP patients. All RP patients were readmitted for…
November 2, 2020
Epidemiological and Clinical Findings of Short-Term Recurrence of Severe Acute Respiratory Syndrome Coronavirus 2 Ribonucleic Acid Polymerase Chain Reaction Positivity in 1282 Discharged Coronavirus Disease 2019 Cases: A Multicenter, Retrospective, Observational Study
A retrospective study of patients who tested positive for SARS-CoV-2 RNA after being discharged from the hospital found that short-term recurrence of positive SARS-CoV-2 RNA was common (15%), and not associated with new symptoms. Risk of onward transmission among those with recurrence was low. Of 1282 discharged patients, almost 15% retested positive during 28-day follow-up, which…
October 29, 2020
Positive RT-PCR Test Results in 420 Patients Recovered From COVID-19 in Wuhan: An Observational Study
An observational study among 420 recovered COVID-19 patients in Wuhan, China suggests that recurrence rates (based on RT-PCR tests) may be lower among patients receiving a comprehensive intervention. The intervention consisted of a combination of treatments including Baduanjin execise, Chinese herbal medicine, moxibustion with acupoint application, and foot baths. Recurrence positivity rates were significantly lower…
August 31, 2020
COVID-19 Re-Infection by a Phylogenetically Distinct SARS-Coronavirus-2 Strain Confirmed by Whole Genome Sequencing
A second episode of infection following recovery from an initial SARS-CoV-2 infection was observed in a patient from Hong Kong who was re-infected after traveling to Europe. The two episodes were confirmed by sequencing of the viral strains from each episode, which occurred 4.5 months apart. The patient was described as being in good health…
Genomic Evidence for a Case of Reinfection with SARS-CoV-2
Tillett et al. found evidence of SARS-CoV-2 re-infection by identifying two viruses with distinct genetic sequences corresponding to two different periods of illness in the same person. The two positive specimens were collected 48 days apart from a patient in Nevada. In between collection of the two positive samples, the patient made a full symptomatic…
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