The Role of Anti-Hypertensive Treatment, Comorbidities and Early Introduction of LMWH in the Setting of COVID-19: A Retrospective, Observational Study in Northern Italy

Result for
Tag: report

September 30, 2020

The Role of Anti-Hypertensive Treatment, Comorbidities and Early Introduction of LMWH in the Setting of COVID-19: A Retrospective, Observational Study in Northern Italy

Chronic treatment with the antihypertensive medications angiotensin converting enzyme inhibitors (ACE-I) and early treatment with low-molecular-weight heparin (LMWH) were both associated with lower in-hospital mortality in a cohort of patients hospitalized with COVID-19 in Italy (n=575), after adjusting for age. Angiotensin receptor blockers, which are also antihypertensive agents acting on the same physiological pathway, were…

Comparative Study of Four SARS-CoV-2 Nucleic Acid Amplification Test (NAAT) Platforms Demonstrates That ID NOW Performance Is Impaired Substantially by Patient and Specimen Type

The nucleic acid amplification test (NAAT) platform Abbott ID NOW performed significantly worse than similar tests (Abbott m2000, DiaSorine Simplexa, and Cepheid Xpert) in detecting SARS-CoV-2 RNA in a comparative study. All four tests were used in parallel on nasopharyngeal and nasal samples from 88 emergency department and hospital-admitted patients. In particular, the ID NOW…

Efficacy and Safety of Hydroxychloroquine vs Placebo for Pre-Exposure SARS-CoV-2 Prophylaxis Among Health Care Workers

Daily administration of hydroxychloroquine to hospital-based healthcare workers as pre-exposure prophylaxis against SARS-CoV-2 infection did not change infection risk between participants receiving hydroxychloroquine vs placebo (6.3% vs 6.6%, p>0.99) in this randomized, double-blind, placebo-controlled trial (n=132). The trial was terminated early due to futility and may have been underpowered to detect clinically important differences. Abella…

September 28, 2020

The Association between Influenza Vaccination and the Risk of SARS-CoV-2 Infection Severe Illness and Death a Systematic Review of the Literature

[Pre-print, not peer-reviewed] A systematic review of 12 studies found that receiving seasonal influenza vaccination was not associated with greater risk of SARS-CoV-2 infection or disease severity in any studies. Several studies found that influenza vaccination was associated with lower risk of SARS-CoV-2 infection, while others found no relationship (7 studies, 242,323 patients). Similarly, several…

COVID-19 Trends Among School-Aged Children — United States, March 1–September 19, 2020

The incidence of SARS-CoV-2 infection in school-age children increased from March and peaked in July and August, followed by a decline in September. During March 1–September 19, 2020, the US reported a total of 277,285 laboratory-confirmed cases of COVID-19 in school-aged children. The average weekly COVID-19 incidence among adolescents aged 12–17 years was approximately…