Alliance for Pandemic Preparedness

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October 30, 2020

Rehabilitation and COVID-19: A Rapid Living Systematic Review 2020 by Cochrane Rehabilitation Field

Updates to a living systematic review of the rehabilitation needs of patients with COVID-19 found that there was evidence to suggest that rehabilitation, including pulmonary rehabilitation, should be recommended to patients with COVID-19 during acute illness. In addition, while prone positioning was found to be associated with lower mortality than positioning patients in the semi-prone…

September 24, 2020

Decreased Mortality in COVID-19 Patients Treated with Tocilizumab: A Rapid Systematic Review and Meta-Analysis of Observational Studies

Tocilizumab was associated with a lower mortality (RR:0.27, 95% CI: 0.12-0.59; risk difference 12%, 95% CI: 4.6%-20%) based on pooled data from 10 studies comprising 1358 patients with COVID-19. The number needed to treat was 11, suggesting that 1 death is prevented for every 11 patients with severe COVID-19 treated with tocilizumab. No differences in…

September 23, 2020

Occurrence and Transmission Potential of Asymptomatic and Presymptomatic SARS-CoV-2 Infections: A Living Systematic Review and Meta-Analysis

A meta-analysis of 94 studies reported that 20% of people who become infected with SARS-CoV-2 remain asymptomatic throughout the infection. The meta-analytic estimate showed a non-significantly lower secondary attack rate in contacts of people with asymptomatic infection compared to those with symptomatic infection (RR=0.35, 95%CI 0.10-1.27). The authors conclude that a combination of prevention measures,…

September 15, 2020

SARS-CoV-2 Recurrent RNA Positivity after Recovering from Coronavirus Disease 2019 (COVID-19): A Meta-Analysis

A systematic review found that the estimated cumulative proportion of recurrent RNA positivity in recovered COVID-19 patients was 12% (95% CI: 12-13%), ranging from 7-23% across studies and with follow-up testing between 1 and 60 days. Mattiuzzi et al. (Sept 7, 2020). SARS-CoV-2 Recurrent RNA Positivity after Recovering from Coronavirus Disease 2019 (COVID-19): A Meta-Analysis….

September 9, 2020

Acute Kidney Injury and Kidney Replacement Therapy in COVID-19: A Systematic Review and Meta-Analysis

• A meta-analysis of 142 studies (49,048 hospitalized COVID-19 patients) reported a pooled incidence of acute kidney injury (AKI) of 29% (95%CI 20%-40%) in the US and Europe (20 studies) and 6% (95%CI 4%-7%) in China (62 studies). Overall AKI was associated with 4.6-fold increased mortality. Fu et al. (Sept 2, 2020). Acute Kidney Injury…

September 4, 2020

Exploring Options for Reprocessing of N95 Filtering Facepiece Respirators (N95-FFRs) amidst COVID-19 Pandemic a Systematic Review

[Pre-print, not peer reviewed] Twenty-one different types of decontamination or reprocessing methods for N95 masks have been evaluated, the most common of which is ultraviolet irradiation. Other techniques found by this systematic review include moist and dry heat and exposure to chemicals, such as ethylene oxide and hydrogen peroxide. Paul et al. (Sept 3, 2020)….

September 2, 2020

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 A Meta-Analysis

A meta-analysis of 7 randomized trials conducted in 12 countries and including 1,703 critically ill patients with COVID-19 found that administration of systemic corticosteroids, compared with usual care or placebo, was associated with lower 28-day all-cause mortality (OR=0.7, 95%CI 0.5-0.8). Serious adverse events occurred in 64/354 (18%) patients who were randomized to corticosteroids and 80 events…

August 27, 2020

Rapid, Point-of-Care Antigen and Molecular-Based Tests for Diagnosis of SARS-CoV-2 Infection

A Cochrane review of rapid tests for SARS-CoV-2 infection (18 cohorts,3,198 samples) evaluated the diagnostic accuracy of five point-of-care antigen tests and four rapid molecular assays. They report the average sensitivity of antigen tests was 56% (95%CI 30-80%) and specificity was 99% (98-100%) based on five studies with 943 samples. The average sensitivity of rapid…