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Tag: risk factors
September 23, 2020
Risk Factors for Hospitalization, Mechanical Ventilation, or Death Among 10 131 US Veterans With SARS-CoV-2 Infection
In a national cohort of 88,747 veterans in the US, 11% tested positive for SARS-CoV-2 from February to May 2020. Veterans with positive PCR results were predominantly male (91%) with a mean age of 64 (SD=16) years. Positive patients had increased rates of 30-day hospitalization (aHR=1.1), mechanical ventilation (aHR=4.2), and death (aHR=4.4). Among positive patients,…
Association of Red Blood Cell Distribution Width With Mortality Risk in Hospitalized Adults With SARS-CoV-2 Infection
An elevated level of red blood cell distribution width (RDW, >14.5%) at hospital admission was associated with an increased mortality risk among 1,461 patients diagnosed with SARS-CoV-2 infection in Boston (RR=2.7). In addition, patients whose RDW increased during hospitalization had higher mortality compared with those whose RDW did not change (6% vs 24% among 1,173…
September 1, 2020
Exposure and Risk Factors for COVID-19 and the Impact of Staying Home on Michigan Residents
[Pre-print, not peer reviewed] A survey of Michigan Medicine biorepository participants (n=8,407, 133 COVID-19 cases) found that risk factors for COVID-19 included African American race (6% of African American participants reported COVID-19 vs 2% for White participants), younger age (51 years among participants reporting COVID-19 vs 59 among participants not reporting COVID-19), and being an…
August 26, 2020
Sex Differences in Immune Responses That Underlie COVID-19 Disease Outcomes
Takahashi et al. found immune responses to SARS-CoV-2 infection differ by sex, suggesting potential factors that contribute to observed sex-based disparities in COVID-19. Among patients with moderate disease who had not received immunomodulatory medications (n=98), male patients had higher plasma levels of innate immune cytokines (e.g., IL-8 and IL-18), along with more robust induction of…
August 24, 2020
Risk for Severe COVID-19 Illness Among Teachers and Adults Living With School-Aged Children
A nationally representative survey in the US shows that 40% of teachers have “definite” risk factors for severe COVID-19 illness (according to CDC criteria) and 51% have “definite” or “possible” risk factors, based on results from the 2018 National Health Interview Survey. Among adults living with school-aged children, 41% have definite and 54% have definite…
SARS-CoV-2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study
[pre-print, not peer-reviewed] In a cohort of children and adolescents who had close contact with a person with known SARS-CoV-2 infection (n=382), SARS-CoV-2-infected children (n=293) were more likely to be Hispanic (88% vs 57%), less likely to have asthma (6% vs 17%), and more likely to have an infected sibling contact (49% vs 29%), compared…
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