Result for
Tag: sequelae
June 15, 2021
Persistent COVID-19 Symptoms Are Highly Prevalent 6 Months after Hospitalization: Results from a Large Prospective Cohort
Nearly 1 in 4 individuals hospitalized for COVID-19 had 3 or more persistent symptoms 6 months after hospital admission in a cohort study in France (n=1,137). Presence of 3 or more symptoms at 6 months was more common among women, those with 3 or more symptoms at admission, and those who were admitted to the…
June 10, 2021
Clinical and Molecular Characteristics of COVID-19 Patients with Persistent SARS-CoV-2 Infection
COVID-19 patients with extended viral shedding for >45 days (n=12) had lower levels of inflammatory cytokines/chemokines (IL-2, TNF, and LT-α) compared to an age- and sex-matched cohort of COVID-19 patients in whom viral shedding resolved within 21 days (n=39). Single-cell RNA sequencing from peripheral mononuclear blood cells from a subset of patients showed suppressed T…
June 8, 2021
Long-COVID Following Mild SARS CoV-2 Infection Characteristic T Cell Alterations and Response to Antihistamines
[Pre-print, not peer-reviewed] “Long COVID” patients with persistent symptoms (mean symptom duration 269 days) treated with histamine receptor antagonists (HRA) (n=25) reported an average reduction in symptom burden by 60%. 20% reported complete symptom resolution, 52% experienced some improvement, and 6 reported no change with a mean time to response of 30 days. By contrast,…
May 28, 2021
6-Month Multidisciplinary Follow-up and Outcomes of Patients with Paediatric Inflammatory Multisystem Syndrome (PIMS-TS) at a UK Tertiary Paediatric Hospital: A Retrospective Cohort Study
Organ-specific sequelae were uncommon at the 6-month follow-up in a cohort of children aged <18 years (median age 10.2 years) diagnosed with pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (n=46). Echocardiograms were normal in 96% of patients, and gastrointestinal symptoms were only present in 13% of patients at 6 months among those with baseline…
May 27, 2021
Assessment of the Frequency and Variety of Persistent Symptoms Among Patients With COVID-19
A systematic review of 45 studies including 9,751 participants with COVID-19 found the most frequent persistent symptoms (≥60 days) included shortness of breath (median 36% of participants in 26 studies), fatigue (median 40% in 25 studies), and sleep disorder (median 30% in 8 studies). A median of 73% of participants in 16 studies of mostly…
May 25, 2021
Post-COVID Syndrome in Non-Hospitalised Patients with COVID-19: A Longitudinal Prospective Cohort Study
Shortness of breath, fatigue, loss of smell, and loss of taste persisted in 9%, 10%, 12%, and 11%, respectively, in a cohort of 442 individuals with COVID-19 (mostly mild cases) who were followed up at 4 months post-infection in Germany. At least one of these characteristic symptoms was present in 123 participants at both the…
Symptoms After COVID-19 Vaccination in Patients With Persistent Symptoms After Acute Infection: A Case Series
In a case series of 36 participants from the UK with persistent COVID-19 symptoms 8 months after hospitalization, 71% of reported symptoms present prior to vaccination with a COVID-19 vaccine were unchanged a median of 1 month after receiving the first dose. 23% of symptoms had improved, and 6% had worsened. Prior to vaccination, participants…
May 21, 2021
Risk of Clinical Sequelae after the Acute Phase of SARS-CoV-2 Infection: Retrospective Cohort Study
A large retrospective cohort study of US adults aged 18-65 enrolled in commercial insurance (N=9,247,505) found that 14% of individuals with documented SARS-CoV-2 infection developed at least 1 new clinical sequala requiring medical care after the acute phase of COVID-19 disease. In comparison, 9% of persons without SARS-CoV-2 infection and 13% of persons with a…
May 20, 2021
Population-Based Estimates of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) Prevalence and Characteristics
Persistent COVID-19 symptoms 30 days and 60 days after symptom onset were present in 53% and 35% of participants, respectively, in a population-based survey in Michigan (n=593). Prevalence of 30-day and 60-day symptoms was 40% higher in hospitalized patients than in non-hospitalized patients, while those who reported very severe symptoms (vs mild) had a 2-fold…
May 17, 2021
Psychological Distress, Persistent Physical Symptoms, and Perceived Recovery After COVID-19 Illness
Patients experiencing COVID-19-related post-traumatic stress disorder (PTSD) and depression had a higher burden of persistent physical symptoms and were less likely to report feeling recovered 3 months after illness onset, according to a study of adults hospitalized between March 26 and May 27, 2020 in New York. Thirty-six percent of patients reported full recovery from…
Next page