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Tag: sequelae
May 12, 2021
Evolution of COVID-19 Symptoms during the First 9 Months after Illness Onset
[Pre-print, not peer-reviewed] In a cohort of COVID-19 patients from the Netherlands (n=301) 82% of patients recovering from severe/critical disease reported at least one persistent symptom 12 weeks after illness onset, compared to 33% and 64% among those recovering from mild to moderate disease, respectively. At nine months after illness onset, 42% of participants continued…
May 10, 2021
Self-Reported Smell and Taste Recovery in Coronavirus Disease 2019 Patients: A One-Year Prospective Study
More than 20% of patients surveyed in Italy who recovered from mild-to-moderate symptomatic COVID-19 reported altered sense of smell or taste one year after initial symptom onset (prevalence = 57/286, 21%). 34 participants reported both smell and taste dysfunction, while 15 reported smell impairment alone and 5 taste disorder alone after 1 year. Of 187…
May 5, 2021
Persistent Neuropsychiatric Symptoms after COVID-19 a Systematic Review and Meta-Analysis
[Pre-print, not peer-reviewed] In a systematic review and meta-analysis of neuropsychiatric symptoms in COVID-survivors (51 studies of 18,917 COVID-19 survivors), sleep disturbance was the most common neuropsychiatric symptom with a pooled prevalence of 27%, followed by fatigue (24%), objective cognitive impairment (also known as brain fog, 20%), anxiety (19%), and post-traumatic stress (16%). Mean duration…
April 28, 2021
Half-year Follow-up of Patients Recovering from Severe COVID-19: Analysis of Symptoms and Their Risk Factors
More than half (55.4%, n = 441) of patients who recovered from severe COVID-19 had persistent symptoms (“sequelae”) at six months follow-up. The most common symptoms were fatigue (25.3%), sleep disorder (23.2%) and shortness of breath (20.4%). Compared to those who had been severely ill (defined as hypoxia without respiratory failure), individuals who had been…
April 27, 2021
Fatigue Symptoms Associated with COVID-19 in Convalescent or Recovered COVID-19 Patients a Systematic Review and Meta-Analysis
[Pre-print, not peer-reviewed] Fatigue was more 3.7-fold as common among patients recovering from COVID-19 compared to healthy controls, according to a systematic review of 39 studies (n=8,825 patients). Over half of hospitalized patients reported symptoms of fatigue up to two months after discharge. Female gender was associated with greater self-reported fatigue and self-report of fatigue…
Risk Factors for Long Covid in Previously Hospitalised Children Using the ISARIC Global Follow-up Protocol A Prospective Cohort Study
[Pre-print, not peer-reviewed] 24% of children hospitalized with COVID-19 in Moscow, Russia reported persistent symptoms at approximately 1 year post-discharge (n=518; median age 10 years). The most commonly reported symptoms were fatigue, followed by sleep disturbance and sensory problems. Persistent symptoms were more common among those aged 6-18 years compared to patients aged <2 years,…
6-Month Follow Up of 8679 Hospitalized COVID-19 Patients in Germany A Nationwide Cohort Study
[Pre-print, not peer-reviewed] 180-day mortality was 30% in a large cohort (n=8,679; median age 72 years) from Germany hospitalized with COVID-19 from February to April 2020. 180-day mortality was 52% among patients aged ≥80 years and 53% for patients who had undergone invasive mechanical ventilation. Coagulopathy, BMI ≥ 40, and age were risk factors for…
Impaired Diffusing Capacity for Carbon Monoxide Is Common in Critically Ill Covid-19 Patients at Four Months Post-Discharge
Impaired lung function was present in 52% of COVID-19 patients four months after discharge from the ICU from March to July 2020 (n=60). The most prevalent impairment was lower than normal diffusing capacity for carbon monoxide (DLCO) (45%). Impaired DLCO was more common among those aged >60 years and those who received invasive mechanical ventilation…
April 23, 2021
Health Care Utilization and Clinical Characteristics of Nonhospitalized Adults in an Integrated Health Care System 28 – 180 Days After COVID-19 Diagnosis — Georgia, May 2020–March 2021
Among adult patients with SARS-CoV-2 who were not hospitalized and who were enrolled in an integrated health system in Georgia, approximately two thirds had at least 1 outpatient medical encounter 28–180 days after diagnosis, and approximately two thirds of these persons received a new primary diagnosis at one or more visits. New diagnoses included cough,…
April 22, 2021
High-Dimensional Characterization of Post-Acute Sequalae of COVID-19
COVID-19 patients who survived beyond the first 30 days of illness (n>73,000) had a 1.6-fold increased risk of death compared those who did not have COVID-19 and were not hospitalized (n>4.9 million), according to analysis of databases from the Department of Veterans Affairs. The cohort study also examined 6-month incident sequelae and found that COVID-19…
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