Alliance for Pandemic Preparedness

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November 4, 2020

Frequency and Profile of Objective Cognitive Deficits in Hospitalized Patients Recovering from COVID-19

[Preprint, not peer-reviewed] Cognitive impairments were found frequently in patients recovering from severe COVID-19 in an inpatient rehabilitation facility. A cross-sectional study tested 57 patients with a mean age of 65 years using standard measures of memory and executive function and found that 81% had cognitive impairment, with deficits most common in working memory (55%),…


SARS-CoV-2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study

A prospective cohort study in North Carolina found that 77% of children and adolescents living with a close household contact infected with SARS-CoOV-2 had a positive SARS-COV2 PCR test. Hispanic ethnicity (OR=1.5) and having an infected sibling close contact (OR=1.7) were associated with increased infection risk. One or more symptoms were reported by 70% of…


Association of COVID-19 RT-QPCR Test False-Negative Rate with Patient Age Sex and Time since Diagnosis

[Preprint, not peer-reviewed] A study using electronic health records in Israel reported that the 11% of PCR tests for SARS-CoV-2 were negative with 0-5 days of clinical diagnosis among patients who had at least one positive PCR test (n= 521,696). Patients who were female (vs. male: OR=1.7) and patients who were younger (10 vs. 40…


SARS-CoV-2 Detection by Nasal Strips a Superior Tool for Surveillance of Pediatric Populations

In pediatric patients, the use of small strips inserted into each nostril was shown to have a sensitivity of 94% and specificity of 100% for the detection of SARS-CoV-2 when compared to pooled nasopharyngeal swab and throat swab samples. Viral loads of SARS-CoV-2 RNA were similar between paired nasal strip samples and nasal swab samples….


Avoiding versus Contracting COVID-19 On the Effectiveness of Social Distancing at the Level of the Individual

[Preprint, not peer-reviewed] A participant’s behavior during behavioral simulation of social distancing behaviors was associated with the risk of subsequently contracting COVID-19, whereas self-report of these behaviors was not. Results from a survey among 2,120 US residents determined that an individual’s performance in a simulator intended to assess physical positioning was associated with lower risk…


October 29, 2020

Evaluating the Effect of Demographic Factors, Socioeconomic Factors, and Risk Aversion on Mobility during the COVID-19 Epidemic in France under Lockdown: A Population-Based Study

Analysis of mobile phone data in France showed that the March lockdown was effective in reducing population mobility, reducing countrywide displacements from 57 to approximately 20 million trips per day (65% reduction). Mobility drops were strongly associated with regions with active populations, workers employed in sectors highly affected by the lockdown, and hospitalizations. However, anomalous…


October 27, 2020

Longitudinal Observation and Decline of Neutralizing Antibody Responses in the Three Months Following SARS-CoV-2 Infection in Humans

A longitudinal study that followed 65 SARS-CoV-2 infected individuals up to 94 days post onset of symptoms found that the neutralizing antibody (nAb) response to SARS-CoV-2 is typical of an acute viral infection, with an initial peak whose magnitude is dependent upon disease severity, followed by declining titers. Some infected individuals with a high peak…


October 14, 2020

High Food Insecurity in Latinx Families and Associated COVID-19 Infection in the Greater Bay Area California

[Preprint, not peer-reviewed] Increased food insecurity was found in Latinx communities in the San Francisco Bay Area during the COVID-19 pandemic. A series of phone interviews from three separate Latinx cohorts conducted from March to September 2020 in the San Francisco Bay Area (total 375 households, 1,875 individuals) found that only 47% of surveyed Latinx…


Rapid and Low-Cost Sampling for Detection of Airborne SARS-CoV-2 in Dehumidifier Condensate

[Preprint, not peer-reviewed] A simple technique of sampling condensate from a commercial dehumidifier at 24-48 hour intervals identified SARS-CoV2 in a hospital setting. Four portable dehumidifiers obtained from Amazon were stationed at various locations in a Maryland hospital ward over 3 separate 1-week periods (June 29- July 5, July 22-August 10 and September 3-10). Among…


Understanding the Los Angeles County Coronavirus Epidemic The Critical Role of Intrahousehold Transmission

[Preprint, not peer-reviewed] Household structure may play a role in the persistent propagation of COVID-19 epidemic, as suggested by a modeling study describing three phases of the COVID-19 epidemic in Los Angeles County. The model showed that during phase I (March 1-April 4), initial seeding of infection in relatively affluent areas was followed by radial…



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