Result for
Tag: vaccination
April 19, 2021
Humoral and Cellular Immune Responses against SARS-CoV-2 Variants and Human Coronaviruses after Single BNT162b2 Vaccination
[Pre-print, not peer-reviewed] An assessment of humoral and T cell responses against a wild type SARS-CoV-2 strain, variants of concern (B.1.1.7, B.1.351, and P.1), and endemic human coronaviruses (hCov) induced after the Pfizer-BioNTech vaccine found that IgG against the receptor-binding domain of the SARS-CoV-2 S protein was readily detectable at day 14, but inhibition of…
Short‐term Impact of Nursing Home SARS‐CoV‐2 Vaccinations on New Infections, Hospitalizations, and Deaths
A study comparing SARS-CoV-2 infections and hospitalizations in nursing homes (n = 280) that had early vaccine clinics (between December 18, 2020, and January 2, 2021) and later vaccine clinics (between January 3 and January 18, 2021) found that one week following the clinics, nursing homes with earlier clinics had 2.5 fewer incident SARS‐CoV‐2 infections…
April 16, 2021
Disparities in SARS-CoV-2 Vaccination-to-Infection Risk Massachusetts 2020-2021
[Pre-print, not peer-reviewed] An analysis of the distribution of SARS-CoV-2 cases and the number of people vaccinated in Massachusetts indicated that communities with increased socioeconomic vulnerability and higher proportions of Black/Latinx residents had fewer people vaccinated per cumulative number of individuals infected, measured by the vaccination-to-infection risk (VIR) ratio. Improved VIRs were associated with higher…
Safety and Reactogenicity of 2 Doses of SARS-CoV-2 Vaccination in Solid Organ Transplant Recipients
Observed safety and reactogenicity to 2 doses of mRNA vaccines (Moderna and Pfizer-BioNTech) weas similar to that reported in clinical trials among a cohort of US solid organ transplant recipients recruited through social media (n=741). Local site reactions were reported by 85% and 78% of participants and systemic reactions were reported by 49% and 69%…
April 15, 2021
MRNA Vaccination Compared to Infection Elicits an IgG-Predominant Response with Greater SARS-CoV-2 Specificity and Similar Decrease in Variant Spike Recognition
[Pre-print, not peer-reviewed] Immune serological responses against SARS-CoV-2 among 55 recipients of the Pfizer-BioNTech vaccine were dominated by IgG antibody responses compared to more diverse responses (including IgM and IgA) elicited by natural infection among 100 COVID-19 patients. Vaccinated individuals also had decreased breadth of antibody response against endemic human coronaviruses compared to convalescent individuals….
Vaccination Boosts Protective Responses and Counters SARS-CoV-2-Induced Pathogenic Memory B Cells
[Pre-print, not peer-reviewed] SARS-CoV-2 specific B cells isolated from individuals who had recovered from SARS-CoV-2 infection appeared similar to B cells isolated previously described in individuals with chronic infections or inflammation (IgD negative, CD27 negative), according to a longitudinal study of convalescent individuals (n=22). After vaccination, the frequency of IgD/CD27 negative cells (“double negative”) decreased….
Behavioral Nudges Increase COVID-19 Vaccinations Two Randomized Controlled Trials
[Pre-print, not peer-reviewed] Text-based behavioral nudges increased COVID-19 appointment and vaccination rates by 86% and 26%, respectively, in a randomized controlled trial conducted in patients from the University of California Los Angeles Health system (n > 110,000). In the experimental group, receiving text messages, including ownership messages (e.g “claim your dose”) increased the efficacy of…
April 14, 2021
The Balancing Role of Distribution Speed against Varying Efficacy Levels of COVID-19 Vaccines under Variants
[Pre-print, not peer-reviewed] Vaccines with lower efficacy can reduce population-level transmission more than vaccines with higher efficacy if distribution of lower efficacy vaccines was comparatively faster based on findings from a modeling study. A vaccine with 65% and 60% efficacy before and after the variants, respectively, can outperform a vaccine with 95% and 90% efficacy,…
Survey of Behaviour Attitudes Towards Preventive Measures Following COVID-19 Vaccination
[Pre-print, not peer-reviewed] A survey of individuals vaccinated for SARS-CoV-2 in Israel found mask wearing was 21% lower and social distancing was 47% lower than before prior to vaccination, with no differences by sex. Decreases in mask wearing (28%) and social distancing (56.1%) were larger among people under age 50 than people over the age…
High Coverage COVID-19 MRNA Vaccination Rapidly Controls SARS-CoV-2 Transmission in Long-Term Care Facilities
[Pre-print, not peer-reviewed] A study comparing documented SARS-CoV-2 infections and deaths in Spain to counterfactual model predictions from February 6 to March 28, 2021 estimated that after 70% of long-term care facility residents had been fully vaccinated with the Pfizer-BioNTech vaccine, 74% of COVID-19 deaths and 75% of all documented infections were prevented, and transmission…
Previous page Next page