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Tag: vaccines
October 20, 2020
Caregiver Willingness to Vaccinate Their Children against COVID-19: Cross Sectional Survey
An international cross-sectional survey of 1,541 caregivers responsible for care of a child recruited from pediatric clinics conducted from March to May 2020 found that 65% had intentions to vaccinate their child against COVID-19. An intention to vaccinate was more common among caregivers with older children, children with no chronic illness, when fathers complete the…
October 19, 2020
Parents’ and Guardians’ Views on the Acceptability of a Future Covid-19 Vaccine a Multi-Methods Study in England
[Pre-print, not peer-reviewed] Most participants in an acceptability study of a future COVID-19 vaccine in England reported that they would accept a SARS-CoV-2 vaccine for themselves or their child. Participants were more likely to report willingness to accept a COVID-19 vaccine for themselves than for their child and less than 4% of participants reported that…
October 15, 2020
Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates
In an ongoing randomized controlled phase 1 trial of RNA-vaccine candidates BNT162b1 and BNT162b2 (n=195), both vaccine candidates elicited similar dose-dependent SARS-CoV-2 neutralizing titers, which were similar to titers of a panel of SARS-CoV-2 convalescent serum samples. BNT162b2 was associated with a lower incidence and severity of systemic reactions than BNT162b1, particularly in older adults,…
Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial
In a randomized placebo-controlled phase 1/2 trial of a SARS-CoV-2 vaccine candidate, BBIBP-CorV, 192 healthy adults were randomized to receive vaccine (2, 4, or 8 μg) or placebo in a 3:1 ratio, stratified by age (18-59 and ≥60) in phase 1. Adverse reactions within the first 7 days of inoculation were reported by 42 (29%)…
October 12, 2020
Age-Targeted Dose Allocation Can Halve COVID-19 Vaccine Requirements
[Pre-print, not peer reviewed] An age-structured mathematical model investigating age-specific allocation strategies for SARS-CoV-2 vaccines indicated that across 179 countries, the highest priority individuals for vaccination were typically those 30-59 years of age, based on their higher risk of infection and disease, and greater rates of contact. The model assumed that the vaccine would be 70%…
October 7, 2020
Influences on Attitudes Regarding Potential COVID-19 Vaccination in the United States
In a survey of 316 respondents selected to reflect the US population, the majority (68%) were supportive of being vaccinated for COVID-19, but side effects of vaccination, questions about vaccine efficacy, and time spent in clinical testing remained concerns. Longer clinical testing of a hypothetical vaccine, increased efficacy, and having a vaccine that was developed…
An In-Depth Investigation of the Safety and Immunogenicity of an Inactivated SARS-CoV-2 Vaccine
[Pre-print, not peer-reviewed] Administration of two inoculations of an inactivated SARS-CoV-2 vaccine was evaluated as safe and immunogenic in a phase I study in China. A double-blinded trial randomly assigned 192 healthy adults to receive one of the three doses of the vaccine or the placebo at an interval of 14 days or 28 days….
October 6, 2020
Current State of Mass Vaccination Preparedness and Operational Challenges in the United States, 2018- 2019
Interviews from public health and preparedness officials representing 33 jurisdictions across the US reveal that most jurisdictions were not capable of or had not planned for implementation of rapid mass vaccination within a short period of time. Key barriers include an insufficient number of qualified personnel to administer vaccinations, increased patient load, cold chain logistical…
October 5, 2020
A Framework for Equitable Allocation of Vaccine for the Novel Coronavirus
An ad hoc committee of the National Academies of Sciences, Engineering, and Medicine developed an overarching framework to assist policymakers in the domestic and global health communities to plan for equitable allocation of vaccines against SARS-CoV-2. The framework includes four allocation phases of COVID-19 vaccine to the public based on risk-based criteria. Phase 1 includes…
October 2, 2020
Intention to Participate in a COVID-19 Vaccine Clinical Trial and to Get Vaccinated against COVID-19 in France during the Pandemic
Nearly 75% of respondents in an online survey in France said they were likely to get a COVID-19 vaccine, and almost half indicated they might agree to participate in a clinical trial for the vaccine. The anonymous online survey indicated that healthcare workers were more likely to report that they would get vaccinated or participate…
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