Result for
Tag: vaccines
November 23, 2020
The Advisory Committee on Immunization Practices’ Ethical Principles for Allocating Initial Supplies of COVID-19 Vaccine — United States, 2020
The Advisory Committee on Immunization Practices announced 4 ethical principles, in addition to scientific data and implementation feasibility, to assist in developing implementation strategies for the initial allocation of a SARS-CoV-2 vaccine: 1) maximizing benefits and minimizing harms; 2) promoting justice; 3) mitigating health inequities; and 4) promoting transparency. McClung et al. (Nov 23, 2020)….
November 18, 2020
Safety, Tolerability, and Immunogenicity of an Inactivated SARS-CoV-2 Vaccine in Healthy Adults Aged 18-59 Years: A Randomised, Double-Blind, Placebo-Controlled, Phase 1/2 Clinical Trial
An inactivated vaccine produced by Sinovac was safe and immunogenic in early phase clinical testing. In a randomized, double-blind, placebo-controlled, phase 1/2 clinical trial (n=743), healthy adults who received two doses of a b-proprionolactione inactivated SARS-CoV2 vaccine (“CoronaVac”) demonstrated high rates of seroconversion. In phase 1 (n=143), the seroconversion rate after day 28 was 83%…
New Pfizer Results: Coronavirus Vaccine Is Safe and 95% Effective
[Press release, not peer-reviewed] A pre-specified analysis of the Pfrizer mRNA vaccine suggested that the vaccine was 95% efficacious and prevented severe disease, according to a company press-release. 162 cases out of 170 cases of COVID-19 disease occurred in the placebo arm, with 9 out of 10 severe cases occurring in the placebo arm. Similar…
November 16, 2020
Epidemiological Impact of SARS-CoV-2 Vaccination: Mathematical Modeling Analyses
A modeling study that tested scenarios with varying levels of SARS-CoV-2 vaccine efficacy found that a vaccine with prophylactic efficacy of ≥70% could eliminate infection and prevent major outbreaks in scenarios where 80% of the population receives the vaccine. A vaccine with a lower efficacy could still control infection in a scenario with additional reduction…
Moderna’s COVID-19 Vaccine Candidate Meets its Primary Efficacy Endpoint in the First Interim Analysis of the Phase 3 COVE Study
[Press release, not peer-reviewed] The COVID-19 vaccine candidate (mRNA-1273) from Moderna demonstrated 94.5% efficacy in Phase 3 of the COVE study, which is evaluating the effect of the vaccine on disease prevention and severity. Interim results were based on 95 COVID-19 cases, 90 of which were reported in the placebo group and 5 in the…
November 9, 2020
What Pfizer’s landmark COVID vaccine results mean for the pandemic
[Press release, not peer-reviewed] Pfizer and BioNTech announced that the BNT162b2 mRNA vaccine had 90% efficacy in preventing COVID-19 in an interim analysis of an ongoing Phase 3 trial. This is the first SARS-CoV-2 vaccine trial to release Phase 3 efficacy data. The trial includes 43,538 participants, 94 of whom developed COVID-19. The press release…
November 2, 2020
The Views of Ethnic Minority and Vulnerable Communities towards Participation in COVID-19 Vaccine Trials
A qualitative study investigating the perceptions of vaccine trials among people from ethnic minority and vulnerable communities in the UK found that while there was overall agreement that clinical research was necessary, most interviewees expressed extreme discomfort with the idea of attending a hospital for a vaccine trial. Participants highlighted concerns about fear of contracting…
October 30, 2020
Projected COVID-19 Epidemic in the United States in the Context of the Effectiveness of a Potential Vaccine and Implications for Social Distancing and Face Mask Use
[Pre-print, not peer-reviewed] Findings from a study using a dynamic compartmental model of COVID-19 transmission for the four most severely affected states (New York, Texas, Florida, and California) indicated that in the absence of a vaccine, SARS-CoV-2 transmission could be slowed in these states by adherence to strict social distancing guidelines and widespread face mask…
October 26, 2020
Social Media and Vaccine Hesitancy
Communities with a greater use of social media to organize offline political actions had more public concerns about vaccine safety in a cross-national analysis of social media and vaccine hesitancy. Additionally, foreign disinformation campaigns were found to be significantly associated with declining vaccination rates. The study found that a one-point shift upward in the five-point…
October 21, 2020
Factors Associated With US Adults’ Likelihood of Accepting COVID-19 Vaccination
A survey conducted in July, 2020 among a convenience sample of 1,971 US adults reported that preferences related to a hypothetical COVID-19 vaccine were associated with vaccine attributes (e.g., vaccine efficacy, adverse effects, and protection duration) and political factors (e.g., US FDA approval process, national origin of vaccine, and endorsements). Willingness to receive a vaccination…
Previous page Next page