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Tag: variants
April 6, 2021
Genomic Surveillance of Nevada Patients Revealed Prevalence of Unique SARS-CoV-2 Variants Bearing Mutations in the RdRp Gene
A novel SARS-CoV-2 mutation (P323 F/L) in the non-structural protein ORF was identified using a genomic surveillance sample of 200 high quality sequences obtained in Nevada from March to June 2020. Phylogenetic reconstruction of the samples cross-referenced to a subsample of sequences in the Nextstrain global genome database show that variants with the mutation P323L…
April 5, 2021
Infection- and Vaccine-Induced Antibody Binding and Neutralization of the B.1.351 SARS-CoV-2 Variant
Acutely infected COVID-19 patients and those who received the Moderna vaccine had significantly reduced IgG binding to the B.1.351 variant receptor binding domain (RBD) compared to the B.1-lineage RBD-specific IgG response. However, sera containing polyclonal antibodies to the spike protein could still effectively neutralize B.1.351. Individuals with prior infection or vaccinated individuals had a nearly…
April 2, 2021
Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil
4 cases of possible SARS-CoV-2 reinfection characterized by a more severe second episode were identified in a case series in Brazil. In March 2020, all patients recovered from a mild course of COVID-19 and retested with negative PCR results during early April. In the last week of May, all 4 cases reported SARS-CoV-2 symptoms and…
March 31, 2021
Increased Transmissibility of the B.1.1.7 SARS-CoV-2 Variant Evidence from Contact Tracing Data in Oslo January to February 2021
[Pre-print, not peer-reviewed] Within households in Norway, the secondary attack rate of the SARS-CoV-2 B.1.1.7 lineage was 60% higher than that of other variants. The study used contact tracing data from 415 index cases and 2,718 of their close contacts from January 4 to February 28, 2021 to estimate transmissibility and found an absolute increase…
March 30, 2021
SARS-CoV-2 Variant B.1.1.7 Caused HLA-A2+ CD8+ T Cell Epitope Mutations for Impaired Cellular Immune Response
[Pre-print, not peer-reviewed] The SARS-CoV-2 B.1.1.7 variant is associated with reduced CD8+ T cell activation due to at least two specific mutations in ORF1. The authors used algorithms to predict HLA-A2 binding epitopes in both the B.1.1.7 strain and the ancestral Wuhan strain and determined whether these epitopes could activate CD8+ T cells using an…
Preliminary Report on SARS-CoV-2 Spike Mutation T478K
[Pre-print, not peer-reviewed] A novel mutation (T478K) located on the SARS-CoV-2 spike protein was identified in an analysis of over 820,000 genomic sequences deposited on the global genome database GISAID up to March 26, 2021. Since its identification in the beginning of 2021, T478K is present in almost 2% of all sequenced genomes. Among the…
March 29, 2021
Sudden Rise in COVID-19 Case Fatality among Young and Middle-Aged Adults in the South of Brazil after Identification of the Novel B.1.1.28.1 (P.1) SARS-CoV-2 Strain Analysis of Data from the State of Parana
[Pre-print, not peer-reviewed] An analysis of 553,518 cases of SARS-CoV-2 (8,853 fatal) between September 1, 2020 and March 17, 2021 in the Brazilian state of Parana found higher COVID-19 case fatality rates (CFRs) among nearly all age groups that coincided with local identification of the SARS-CoV-2 P.1 variant. All age groups showed either a decline…
Characterizing the Disproportionate Burden of SARS-CoV-2 Variants of Concern among Essential Workers in the Greater Toronto Area Canada
[Pre-print, not peer-reviewed] In the Greater Toronto Area, Canada, SARS-CoV-2 cases defined as variant of concern (VOC) emerged faster in groups with the lowest income (growth rate 43.8%, 34.6%, and 21.6% by income tertile from lowest to highest), and the most essential work (growth rate 18.4%, 30.8%, and 50.8% by essential work tertile from lowest…
March 25, 2021
Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil
SARS-CoV-2 reinfection with a variant harboring the E484K mutation (occurring in the P.2 variant) was confirmed by genome sequencing in a case study in Brazil. The primary infection occurred in May 2020 by a widely circulating variant B.1.1.33 without the E484K mutation, while the reinfection occurred 147 days later in October 2020. Findings from this…
B.1.526 SARS-CoV-2 Variants Identified in New York City Are Neutralized by Vaccine-Elicited and Therapeutic Monoclonal Antibodies
[Pre-print, not peer-reviewed] Neutralizing activity elicited by prior SARS-CoV-2 infection, mRNA vaccines (Pfizer-BioNTech and Moderna), or the Regeneron monoclonal antibody cocktail (REGN10933 and REGN10987) were similar against the B.1.526 variant with the S477N mutation compared to the widely circulating strain with the D614G mutation. In contrast, similar to other E484K harboring variants, the B.1.526 variant…
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