Alliance for Pandemic Preparedness

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January 12, 2021

Empiric Evidence of Ethnic Disparities in Coronavirus Positivity in Washington State

Minority groups experienced higher rates of SARS-CoV-2 positivity compared to white patients in Washington State during the first wave of the pandemic (n=18,667). Latinx patients had nearly a 5-fold risk of positivity compared to white patients, while Black patients had nearly a 2-fold risk of positivity. Notably, 22% of Latinx patients had self-pay insurance compared…


December 16, 2020

Nursing Home Staff Networks and COVID-19. Proceedings of the National Academy of Sciences of the United States of America

A higher degree of connectedness between nursing homes via shared staff and contractors was associated with reporting COVID-19 cases. A large-scale analysis of nursing home connections via shared staff and contractors that used smartphone geolocation data found that 5% of smartphone users who visited a nursing home for at least one hour also visited another…


December 10, 2020

Widespread Testing, Case Isolation and Contact Tracing May Allow Safe School Reopening with Continued Moderate Physical Distancing: A Modeling Analysis of King County, WA Data

Modeling based on King County, Washington State indicates that returning to a level of 75% of pre-COVID-19 physical interactions between May 15-July 15 was projected to result in 350 daily deaths by early September 2020. Maintaining less than 45% of pre-COVID-19 physical interactions was required to ensure low levels of daily infections and deaths. A…


December 9, 2020

Strengthening Policy Coding Methodologies to Improve COVID-19 Disease Modeling and Policy Responses: A Proposed Coding Framework and Recommendations

To address inconsistencies in how policies related to closing and reopening elements of society are described and analyzed, researchers developed a framework to categorize the various policies in place in 12 US states. A comparative content analysis using a 16-element framework, including domains such as bars, restaurants, childcare, and religious gatherings,  revealed high granularity and nuance…


December 8, 2020

Seroprevalence of SARS-CoV-2 Antibodies in Seattle Washington October 2019-April 2020

[Pre-print, not peer reviewed] Residual clinical samples from 763 Seattle-area adults collected during March 5-April 1, 2020 show a seroprevalence of antibodies to SARS-CoV-2 of 1.2%, which was 11 times greater than the number of confirmed cases in King County as of April 1. The authors note, however, that participant sampling in the study may…


November 17, 2020

Continued Age Shift of Confirmed Positive COVID-19 Incidence Over Time to Children and Young Adults Washington State March – August 2020

[Pre-print, not peer reviewed] A longitudinal cohort analysis in Washington State found a shift in the age distribution of confirmed COVID-19 cases from older age groups to young adults and children. From March to April 2020, there was a 10% decline in cases age 60 years and older and a 20% increase among those age…


November 9, 2020

Containment of a COVID-19 Outbreak in an Inpatient Geriatric Psychiatry Unit

An inpatient geriatric psychiatry unit in King County, Washington reported a SARS-CoV-2 outbreak between March 11-18, 2020, with 9 inpatients and 7 staff members with confirmed SARS-CoV-2 infection. Enhanced infection prevention interventions and engagement of frontline psychiatric care staff following the outbreak effectively contained the outbreak, with no further patients and only one staff member…


October 2, 2020

COVID‐19 in Seattle—Early Lessons Learned

An overview of Seattle’s early experience with the COVID-19 response from 6 regional hospitals revealed coordination between many aspects of the healthcare system, including EMS, hospitals and health systems, outpatient networks, public health officials, and government leaders. Seattle implemented triage processes, continuously updated PPE guidelines and isolation measures, increased the availability of testing, and is…


Viral Genomes Reveal Patterns of the SARS-CoV-2 Outbreak in Washington State

[Pre-print, not peer reviewed] The 614G viral variant of SARS-CoV-2 has been hypothesized to be more transmissible than other strains, but findings from Washington State indicate that the increasing dominance of 614G in the state is more likely due to mobility patterns and the effect of control measures rather than viral transmissibility factors. Sequencing of…


September 25, 2020

Assessment of Disparities in COVID-19 Testing and Infection Across Language Groups in Seattle, Washington

Out of a patient population of 562,242 in King County, WA, a slightly lower percentage of non-English speakers had been tested for SARS-CoV-2 compared to English-speakers (5% vs 6%), but the proportion of positive tests was 4.6-fold higher among non-English speakers (19% vs 4%). The elevated proportion of positive tests was observed across multiple languages….



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