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Topic: Clinical Characteristics and Health Care Setting
January 27, 2021
SARS-CoV-2 Serology Levels in Pregnant Women and Their Neonates
A study of the serologic response to SARS-CoV-2 infection in pregnant women (n = 88) found that asymptomatic pregnant women mounted a lower immune response than symptomatic pregnant women, and that maternal IgG antibodies were positively correlated with levels in neonates. Maternal IgM and IgG levels peaked around 15 and 30 days after onset of…
SARS-CoV-2 Infection in Pregnancy Is Associated with Robust Inflammatory Response at the Maternal-Fetal Interface
[Pre-print, not per-reviewed] A study of SARS-CoV-2 in pregnant women showed that in pregnant women with COVID-19, ACE2 is widely expressed in the placenta at term compared to low levels of expression in noninfected mothers. Despite the in vitro susceptibility of cytotrophoblasts (a type of placental cell) to SARS-CoV-2 infection, viral RNA was detected in…
Association of Psychiatric Disorders With Mortality Among Patients With COVID-19
Diagnosis of a schizophrenia spectrum disorder was significantly associated with increased risk of 45-day mortality among adults who tested positive for SARS-CoV-2, after adjusting for demographic and medical risk factors (OR=2.7). The retrospective cohort study enrolled 7,348 individuals at a large medical system in New York, 75 (1%) of whom had a history of a…
January 26, 2021
Pregnancy as a Risk Factor for Severe Coronavirus 2019 (COVID-19) Disease Using Standardized Clinical Criteria
A retrospective cohort study in the US (n=262 women with symptomatic COVID-19) found that compared to non-pregnant women, pregnant women were at significantly increased risk of developing severe COVID-19. After adjusting for ethnicity and insurance status, pregnant patients were between 3.6 and 5.7 times as likely to have severe disease, depending on the criteria used…
January 25, 2021
Increased Infections, but Not Viral Burden, with a New SARS-CoV-2 Variant
[Pre-print, not peer-reviewed] A large community surveillance study in the UK found evidence for increases in S-gene target failures (SGTF) of SARS-CoV-2, consistent with expansion of the B.1.1.7 variant, at a time in mid-November when non-SGTF strains were stable or declining. Data were analyzed from nose and throat swabs (n=1,553,687) collected from September 28, 2020…
Abrupt Increase in the UK Coronavirus Death-Case Ratio in December 2020
[Pre-print, not peer-reviewed] A study evaluating the statistical relationship between COVID-19 infections and reported deaths in the UK identified an increase in the case fatality ratio in December 2020. While deaths were well described as 1/55th of cases detected 12 days prior during the months of October and November, by early December the case fatality…
The Proportion of SARS-CoV-2 Infections That Are Asymptomatic
At least one third of SARS-CoV-2 infections were characterized as asymptomatic in a systematic review of cross-sectional and longitudinal observational studies and reports of mass screening for SARS-CoV-2. Most studies (43/61) used PCR testing of nasopharyngeal swabs to detect current infection, and 18 studies used antibody testing to detect current or prior infection. In 14…
January 22, 2021
Neurological Complications of COVID‐19 in Hospitalized Patients: The Registry of a Neurology Department in the First Wave of the Pandemic
A hospital-based registry found a low prevalence of neurological complications in patients hospitalized for COVID‐19. Among 2,750 people hospitalized for COVID-19 in a single hospital in Spain, 71 (3%) experienced at least one neurological complication within four months of follow-up. The most common diagnoses were neuromuscular disorders (34%), cerebrovascular diseases (27%), acute encephalopathy (19%), and…
Demographic Predictors of Hospitalization and Mortality in US Children with COVID-19
Although deaths and hospitalizations are rare among children in the United States diagnosed with COVID-19, Black and multiracial children are more likely than white children to be hospitalized (OR=1.5) and die (OR=3.0). Children with a prior medical condition are also more likely to be hospitalized (OR=3.6) and to die (OR=8.8). Of the 27,045 children whose…
January 21, 2021
Clinical and Laboratory Features of Hypercoagulability in COVID-19 and Other Respiratory Viral Infections amongst Predominantly Younger Adults with Few Comorbidities
A retrospective cohort study among hospitalized COVID-19 patients (n=181) and patients with other respiratory viral infections (n=165) found similarly low rates of arterial or venous thrombotic events. However, clot waveform analysis parameters were significantly higher among severe than mild COVID-19 patients, suggesting increased risk for hypercoagulability. Patients in the ICU routinely received the thrombosis prevention…
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