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Topic: Clinical Characteristics and Health Care Setting
June 8, 2021
Long-COVID Following Mild SARS CoV-2 Infection Characteristic T Cell Alterations and Response to Antihistamines
[Pre-print, not peer-reviewed] “Long COVID” patients with persistent symptoms (mean symptom duration 269 days) treated with histamine receptor antagonists (HRA) (n=25) reported an average reduction in symptom burden by 60%. 20% reported complete symptom resolution, 52% experienced some improvement, and 6 reported no change with a mean time to response of 30 days. By contrast,…
June 7, 2021
The Role of HIV Infection in the Clinical Spectrum of COVID-19 a Population-Based Cohort Analysis Based on US National COVID Cohort Collaborative (N3C) Enclave Data
[Pre-print, not peer-reviewed] A study using electronic health record data from 54 clinical sites in the National COVID Cohort Collaborative found that people living with HIV (PLWH, n=13,170) had a higher risk of COVID-19 death and hospitalization after adjusting for age and sex. The associations were attenuated, but remained significant, after adjusting for smoking status,…
Plasma ACE2 Predicts Outcome of COVID-19 in Hospitalized Patients
Among patients with COVID-19 (n=306), high plasma levels of angiotensin converting enzyme 2 (ACE2) at hospital admission were associated with increased illness severity within 28 days (OR = 1.8), and plasma ACE2 was significantly higher among patients with hypertension. Circulating ACE2 was also significantly higher in patients with COVID-19 with pre-existing heart conditions and kidney…
June 4, 2021
Inhaled Corticosteroids Do Not Adversely Impact Outcomes in COVID-19 Positive Patients with COPD: An Analysis of Cleveland Clinic’s COVID-19 Registry
A large retrospective cohort study of persons with chronic obstructive pulmonary disease (COPD) (N=27,810) found that inhaled corticosteroid therapy did not increase COVID-19 related healthcare utilization or mortality. There were no statistically significant differences observed in hospitalization, ICU admission, endotracheal intubation, mechanical ventilation, or mortality among persons with a positive SARS-COV-2 test after adjusting for…
Immunological Dysfunction Persists for 8 Months Following Initial Mild-Moderate SARS-CoV-2 Infection
[Pre-print, not peer-reviewed] A prospective cohort study found that persons with persistent symptoms following COVID-19 infection had an elevated diffuse inflammatory cytokine profile at 8 months post SARS-CoV-2 infection, which was not observed in age/gender matched asymptomatic COVID-19 survivors, healthy controls, or persons who survived other human coronaviruses. Additionally, persons with persisting symptoms had a…
Hospitalization of Adolescents Aged 12–17 Years with Laboratory-Confirmed COVID-19 — COVID-NET, 14 States, March 1, 2020–April 24, 2021
A review of COVID-19 associated hospitalizations among adolescents aged 12-17 years (N=204) found that the rate of hospitalization peaked at 2.1 per 100,000 in early January 2021, declined to 0.6 in mid-March, and rose to 1.3 in April. Among hospitalized adolescents, nearly 1 in 3 required ICU admission, 5% required invasive mechanical ventilation, and no…
June 3, 2021
Co-Infections, Secondary Infections, and Antimicrobial Use in Patients Hospitalised with COVID-19 during the First Pandemic Wave from the ISARIC WHO CCP-UK Study: A Multicentre, Prospective Cohort Study
Of 1,080 microbiologically confirmed infections in patients hospitalized for COVID-19 between February and June 2020 in the UK, 762 (70.6%) were secondary, occurring >2 days after hospital admission. Among patients hospitalized for COVID-19 during this period and with available data, 37% (13,390 of 36,1456) had received antimicrobials in the community prior to hospital admission, and…
Carbapenem-Resistant Klebsiella Pneumoniae Infections in ICU COVID-19 Patients—A Scoping Review
A literature review including 10 studies found evidence of hospital-based infection caused by the bacterium Klebsiella pneumoniae that was resistant to the carbapenem class of antibiotics among ICU patients with COVID-19 in 6 countries, ranging in prevalence from 0.35% to 53%. The majority of infected patients were male (85%), with a mean age of 61…
SARS-CoV-2 Infects Syncytiotrophoblast and Activates Inflammatory Responses in the Placenta
[Pre-print, not peer-reviewed] SARS-CoV-2 RNA was detected in 23 placentas (41%) from a cohort of 55 women who had SARS-CoV-2 infection during late pregnancy and had positive PCR results at delivery. Among infected placentas, three had high viral content and were obtained from mothers who presented with severe COVID-19 and had perinatal adverse outcomes. Examination…
May 28, 2021
6-Month Multidisciplinary Follow-up and Outcomes of Patients with Paediatric Inflammatory Multisystem Syndrome (PIMS-TS) at a UK Tertiary Paediatric Hospital: A Retrospective Cohort Study
Organ-specific sequelae were uncommon at the 6-month follow-up in a cohort of children aged <18 years (median age 10.2 years) diagnosed with pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (n=46). Echocardiograms were normal in 96% of patients, and gastrointestinal symptoms were only present in 13% of patients at 6 months among those with baseline…
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