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Topic: Clinical Characteristics and Health Care Setting
November 5, 2020
Clinical Characteristics of Re-Positive COVID-19 Patients in Huangshi, China: A Retrospective Cohort Study
In an observational retrospective cohort study in Huangshi, China, 23 out of 368 recovered COVID-19 patients quarantined for 14 days post-discharge retested positive for SARS-CoV-2. Retesting positivity was associated with a higher ratio of lymphocytes on admission and presence of comorbidities, while negatively associated with a lower peak temperature during hospitalization and arbidol treatment. Zhou…
November 4, 2020
Frequency and Profile of Objective Cognitive Deficits in Hospitalized Patients Recovering from COVID-19
[Preprint, not peer-reviewed] Cognitive impairments were found frequently in patients recovering from severe COVID-19 in an inpatient rehabilitation facility. A cross-sectional study tested 57 patients with a mean age of 65 years using standard measures of memory and executive function and found that 81% had cognitive impairment, with deficits most common in working memory (55%),…
SARS-CoV-2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study
A prospective cohort study in North Carolina found that 77% of children and adolescents living with a close household contact infected with SARS-CoOV-2 had a positive SARS-COV2 PCR test. Hispanic ethnicity (OR=1.5) and having an infected sibling close contact (OR=1.7) were associated with increased infection risk. One or more symptoms were reported by 70% of…
November 3, 2020
The Impact of Substance Use Disorder on COVID-19 Outcomes
Persons with substance use disorders may be more vulnerable to adverse effects of COVID-19, according to a cohort study of COVID-19 patients (n=11,124) matched for demographic characteristics and presence of diabetes and obesity. Analysis showed that substance use disorder was associated with a 1.84-fold increased risk of hospitalization, 1.45-fold increased risk of ventilator use, and…
Symptoms at Presentation for Patients Admitted to Hospital with Covid-19 Results from the ISARIC Prospective Multinational Observational Study
[Pre-print, not peer-reviewed] Results from a large prospective cohort (n=60,161 symptomatic patients with confirmed COVID-19 from 43 countries) found that the most sensitive case definition, which was met by 92% of the cohort, was one or more of cough, shortness of breath, fever, muscle pains or sort throat. These symptoms were more frequent among patients…
Systematic Review and Meta‐analysis of Factors Associated with Re‐positive Viral RNA after Recovery from COVID‐19
A systematic review of 9 studies found that compared to recovered COVID-19 patients who did not experience a recurrent positive PCR test, recovered COVID-19 patients who experienced a recurrent positive test had shorter hospital stay (14.5 vs 15.5 days) and were more likely to have fatigue symptoms, and to test positive for IgM and IgG….
November 2, 2020
Update: Characteristics of Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status — United States, January 22–Oct 3, 2020
Pregnant women with COVID-19 in the US were significantly more likely than nonpregnant women to be admitted to the ICU (aRR = 3.0), receive invasive mechanical ventilation (aRR = 2.9), and to die (aRR = 1.7) after adjusting for age, race/ethnicity, and underlying medical conditions. Although the absolute risks for severe outcomes were low, pregnant…
Birth and Infant Outcomes Following Laboratory-Confirmed SARS-CoV-2 Infection in Pregnancy — SET-NET, 16 Jurisdictions, March 29 – October 14 , 2020
Among infants born to mothers with laboratory-confirmed SARS-CoV-2 infection (n=3,912), 12.9% of live births were preterm (<37 weeks), higher than the reported 10.2% in the general population in 2019. Perinatal infection was infrequent and occurred primarily among infants whose mother had SARS-CoV-2 infection identified within 1 week of delivery. The authors note that since most…
Hospital and ICU Patient Volume per Physician at Peak of COVID Pandemic: State-Level Estimates
A study that used results from the Institute of Health Metrics and Evaluation model to estimate the number of hospitalized and ICU patients per physician expected at the peak of the pandemic in each state found that while most states should have sufficient physician capacity to handle the surge, some states in the Midwest will…
October 30, 2020
Rehabilitation and COVID-19: A Rapid Living Systematic Review 2020 by Cochrane Rehabilitation Field
Updates to a living systematic review of the rehabilitation needs of patients with COVID-19 found that there was evidence to suggest that rehabilitation, including pulmonary rehabilitation, should be recommended to patients with COVID-19 during acute illness. In addition, while prone positioning was found to be associated with lower mortality than positioning patients in the semi-prone…
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