Result for
Topic: Clinical Characteristics and Health Care Setting
March 4, 2020
The Impact of the COVID-19 Outbreak on the Medical Treatment of Chinese Children with Chronic Kidney Disease (CKD): A Multicenter Cross-section Study in the Context of a Public Health Emergency of International Concern
An online survey was distributed to 17 pediatric nephropathy diagnosis and treatment centers in China to gather information on patients, parents, and changes to medical treatment processes since the start of the COVID-19 outbreak. Greatest needs reported by patients and families included online consultation, medication delivery, and psychological counselling, especially for low income children in…
Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China
In a study of 150 COVID-19 patients in Wuhan, case fatality was associated with older age, underlying comorbidities, presence of secondary infection, and inflammatory indicators in the blood. Death may also be related to virus-activated “cytokine storm syndrome” or fulminant myocarditis. Ruan et al. (Mar 3, 2020). Clinical predictors of mortality due to COVID-19 based…
Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential
Xu et al discuss the potential clinical use of niclosamide, an FDA-approved anthelminthic, in treating COVID-19. Xu et al. (Mar 3, 2020). Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential. ACS Infect Dis. https://doi.org/10.1021/acsinfecdis.0c00052
Priorities for the US Health Community Responding to COVID-19
Adalja et al discuss priorities for the US health care community in preparing for COVID-19. Priorities include reviewing and updating preparedness plans developed for prior epidemics, hospital and clinic readiness, rapid expansion of diagnostic testing capacity, and public health interventions to slow spread. Adalja et al. (Mar 4, 2020). Priorities for the US Health Community…
March 3, 2020
A case of 2019 Novel Coronavirus in a pregnant woman with preterm delivery
The authors describe the case of a 30-week pregnant COVID-19 patient who underwent emergency cesarean section and delivered a healthy baby with no COVID-19 infection. Wang et al. (Feb 28, 2020). A case of 2019 Novel Coronavirus in a pregnant woman with preterm delivery. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciaa200
The persistence and clearance of viral RNA in 2019 novel coronavirus disease survivors
RT-PCR results for biological samples of 66 recovering COVID-19 patients were used to evaluate SARS-CoV-2 clearance time and influencing factors. Viral clearance in stool samples was delayed compared to oropharyngeal swabs. Furthermore, this delay was pronounced among patients who were treated with corticosteroids, suggesting that treatment with corticosteroids should be considered with caution. Ling et…
Coronavirus disinfection in histopathology
This paper offers recommendations for laboratory safety and disinfection methods for use in histotechnology processes. Henwood (Mar 1, 2020). Coronavirus disinfection in histopathology. Journal of Histotechnology. https://doi.org/10.1080/01478885.2020.1734718
Clinical Data on Hospital Environmental Hygiene Monitoring and Medical Staff Protection during the Coronavirus Disease 2019 Outbreak
Jiang et al describe a study of air and surface contamination in a Chinese hospital to evaluate environmental hygiene and to support improved infection control practices. Jiang et al. (Mar 2, 2020). Clinical Data on Hospital Environmental Hygiene Monitoring and Medical Staff Protection during the Coronavirus Disease 2019 Outbreak. Pre-print downloaded Mar 3 from https://doi.org/10.1101/2020.02.25.20028043
Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely associated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients
Detectable serum SARS-CoV-2 viral load appears to be associated with increased illness severity. Inflammatory cytokine IL-6 levels were also 10 times higher among critically ill patients compared to other patients. Chen et al. (Mar 3, 2020). Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely associated with drastically elevated interleukin 6 (IL-6) level in critically ill…
March 2, 2020
Coronavirus Disease 2019: Coronaviruses and Blood Safety
With concerns around asymptomatic transmission, authors offer recommendations for blood safety in areas with known spread. They also provide inactivation methods for coronaviruses in blood products and laboratory tissue culture. Chang et al. (Feb 21, 2020) Coronavirus Disease 2019: Coronaviruses and Blood Safety. Transfusion Medicine Review 29, 203s. https://doi.org/10.1016/j.tmrv.2020.02.003
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