Result for
Topic: Geographic Spread
June 15, 2021
Antibodies to SARS-CoV-2 in All of Us Research Program Participants, January 2-March 18, 2020
SARS-CoV-2 antibodies were detected in persons from diverse geographic regions in the US prior to the first syndromic cases identified by PCR, according to analysis of samples collected as part of the All of Us study. The All of Us study was started in 2018 and has enrolled a diverse population of US adults from…
Rapidly Emerging SARS-CoV-2 B.1.1.7 Sub-Lineage in the United States of America with Spike Protein D178H and Membrane Protein V70L Mutations
Genomic surveillance of SARS-CoV-2 cases identified an expanding US-specific sub-lineage of the B.1.1.7 (Alpha) variant. This sub-lineage is characterized with sequential acquisition of a membrane protein mutation, V20L, in November 2020 and a spike mutation, D178H, in early February 2021. The proportion of B.1.1.7 (Alpha) isolates in the US belonging to this sub-lineage increased from…
June 11, 2021
SARS-CoV2 Spike Protein Gene Variants with N501T and G142D Mutation-Dominated Infections in Mink in the United States
An analysis of SARS-CoV-2 sequences isolated from farmed mink populations (N=977) and human infections in the US and Canada (N=192,806) from December 2019-March 2021 revealed that the N501T mutation was found in humans two months prior to being detected in mink populations. However, in contrast to the N501Y mutation, which is present in the B.1.1.7…
June 10, 2021
Genomic Surveillance for SARS-CoV-2 Variants Circulating in the United States, December 2020–May 2021
During April 11-24, 2021, the SARS-CoV-2 B.1.1.7 (Alpha) variant accounted for an estimated 66% of US infections and the P.1 (Gamma) variant accounted for 5% of US infections, according to the CDC. Estimates are based on sequencing of 25,000 SARS-CoV-2-positive specimens, representing 3% of all reported positive tests and weighted to the general population. Estimated…
June 7, 2021
2020 SARS-CoV-2 Diversification in the United States Establishing a Pre-Vaccination Baseline
[Pre-print, not peer-reviewed] A study investigating SARS-CoV-2 genetic diversity in the US using sequences publicly available prior to December 15th, 2020, when vaccination was initiated in the U.S., found that the regional distribution of COVID-19 cases varied by pandemic phase and was not always correlated with the level of viral sequencing in different regions. In…
June 3, 2021
Structural Analysis of the Novel Variants of SARS-CoV-2 and Forecasting in North America
A forecasting model incorporating North American prevalence of SARS-CoV-2 variants of concern from the genome database GISAID suggests that the B.1.1.7 variant could become dominant (>60% of sequenced strains) by summer 2021 but would sharply decrease in frequency when 75% of the population is immune through vaccination or natural infection due to its high binding…
June 2, 2021
Analysis of SARS-CoV-2 Mutations Reveals Three Types of Temporal Dynamics and One Is Correlated with International Travels
[Pre-print, not peer-reviewed] Analysis of over 1 million SARS-CoV-2 genomes identified 115 non-synonymous mutations estimated to be present in >3% of global COVID-19 cases. COVID-19 cases were identified from 714 country-month combinations from 98 countries. High frequency mutations were defined as frequency changes occurring between a >15% increase and <5% decrease over 2 months, including…
May 27, 2021
Emergence of a New SARS-CoV-2 Variant from GR Clade with a Novel S Glycoprotein Mutation V1230L in West Bengal India
[Pre-print, not peer-reviewed] Genomic surveillance detected a potential new variant emerging in West Bengal, India from an analysis of over 2,000 sequenced samples collected from January to March 2021. The new variant, identified in 70 of 412 sequences submitted from West Bengal, is characterized by 11 mutations including V1230L and P681H, also found in the…
May 21, 2021
Emergence and Spread of the Potential Variant of Interest (VOI) B.1.1.519 Predominantly Present in Mexico
[Pre-print, not peer-reviewed] Investigators described the emergence and spread of a novel SARS-CoV-2 variant of interest (B.1.1.519) in Mexico with mutations T478L, P681H, and T732A in the spike protein. Out of 2,692 SARS-CoV-2 samples analyzed for genomic sequence between March 1, 2020 and March 21, 2021, 37.8% were B.1.1.519. The variant was not detected prior…
May 19, 2021
Rapidly Emerging SARS-CoV-2 B.1.1.7 Sub-Lineage in the United States of America with Spike Protein D178H and Membrane Protein V70L Mutations
[Pre-print, not peer-reviewed] Genomic surveillance of SARS-CoV-2 cases identified an expanding US-specific sub-lineage of the B.1.1.7 variant. This sub-lineage is characterized with sequential acquisition of a membrane protein mutation, V20L, in November 2020 and a spike mutation, D178H, in early February 2021. The proportion of B.1.1.7 isolates in the US belonging to this sub-lineage increased…
Next page