Result for
Topic: Testing and Treatment
August 28, 2020
Self-Diagnosed COVID-19 in People with Multiple Sclerosis: A Community-Based Cohort of the UK MS Register
A prospective observational cohort study found that people with multiple sclerosis (MS) and those taking immunomodulatory disease-modifying therapies were not at elevated risk of COVID-19. Among people with MS, 237 of 3,910 (6%) participants reported self-diagnosed COVID-19, which was a similar risk to among their siblings without MS (OR: 1.2, 95%CI: 0.9-1.6). Participants taking disease-modifying…
Low-Dose Hydroxychloroquine Therapy and Mortality in Hospitalized Patients with COVID-19: A Nationwide Observational Study of 8075 Participants
Catteau et al. conducted a retrospective analysis of in-hospital mortality using Belgian national COVID-19 hospital surveillance data (n=8,075) and found that, after adjusting for clinical and demographic features, mortality was lower among patients who received low-dose hydroxychloroquine (2400 mg over 5 days) compared to supportive care alone (HR=0.7, 95%CI: 0.6-0.8). Catteau et al. (Aug 24,…
Impact of Famotidine Use on Clinical Outcomes of Hospitalized Patients With COVID-19
A retrospective propensity-matched observational study (n=878) found that famotidine, a histamine-2 blocker used to treat acid reflux and ulcers, was associated with a decreased risk of in-hospital mortality (OR=0.4, 95% CI: 0.2-0.96) as well as combined outcome of death or intubation (OR=0.5, 95% CI: 0.2-0.96). While patients treated with famotidine were younger (63.5 +/- 15…
August 27, 2020
Rapid, Point-of-Care Antigen and Molecular-Based Tests for Diagnosis of SARS-CoV-2 Infection
A Cochrane review of rapid tests for SARS-CoV-2 infection (18 cohorts,3,198 samples) evaluated the diagnostic accuracy of five point-of-care antigen tests and four rapid molecular assays. They report the average sensitivity of antigen tests was 56% (95%CI 30-80%) and specificity was 99% (98-100%) based on five studies with 943 samples. The average sensitivity of rapid…
August 26, 2020
Diagnosis of SARS-CoV-2 in Children Accuracy of Nasopharyngeal Swab Compared to Nasopharyngeal Aspirate
[pre-print, not peer-reviewed] Comparing the diagnostic performance of nasopharyngeal swab (NS) to nasopharyngeal aspirate (NPA) for the detection of SARS-CoV-2 in children (n=300 paired samples), NS was found to have a low sensitivity in detecting SARS-CoV-2 in children when referred to NPA. The authors recommend that in children under 6 years of age, NS should…
Saliva Sample Pooling for the Detection of SARS-CoV-2
Pasomsub et al. showed that pooling of either five or ten saliva samples for testing by SARS-CoV-2 RT-PCR did not compromise the detection of SARS-CoV-2. Pasomsub et al. (Aug 25, 2020). Saliva Sample Pooling for the Detection of SARS-CoV-2. Journal of Medical Virology. https://doi.org/10.1002/jmv.26460
Hydroxychloroquine in the Treatment of Outpatients with Mildly Symptomatic COVID-19 A Multi-Center Observational Study
[pre-print, not peer-reviewed] In a retrospective observational study of SARS-CoV-2 infected non-hospitalized patients (n=1,274), hydroxychloroquine exposure was associated with a decreased rate of hospitalization from COVID-19 in a 1,067 patient propensity score matched cohort (OR=0.53, 95%CI 0.29, 0.95). Among outpatients treated with hydroxychloroquine 22% with were hospitalized compared to 32% who did not receive hydroxychloroquine….
August 25, 2020
Universal Testing for Coronavirus Disease 2019 in Pregnant Women Admitted for Delivery: Prevalence of Peripartum Infection and Rate of Asymptomatic Carriers at Four New York Hospitals within an Integrated Healthcare System
Blitz et al. conducted a retrospective cohort study evaluating women admitted for delivery at 4 hospitals in a New York health system between April 2-9 (n=382) and found a 19% prevalence of COVID-19. Hispanic and non-Hispanic black women were found to be disproportionately affected, and asymptomatic carriers were common (70%) across all 4 sites. Blitz…
Diagnostic Yield of Repeat Testing for SARS-CoV-2: Experience from a Large Health System in Los Angeles
Adamson et al. conducted a retrospective analysis of 10,165 SARS-CoV-2 test results from the UCLA Health System to determine the diagnostic yield of repeat testing and found that among 808 patients who did repeat testing following an initial negative test, only 2% subsequently tested positive. Investigators suggest certain clinical scenarios may benefit from repeat testing,…
August 24, 2020
Convalescent Plasma for Patients with Severe COVID-19 a Matched Cohort Study
[pre-print, not peer-reviewed] Rogers et al. found no significant difference in the risk of in-hospital mortality among patients with severe COVID-19 who received convalescent plasma (n=64) and patients with severe COVID-19 (n=177) who did not receive it in an observational study. Although there was no significant difference in the overall rate of hospital discharge, a…
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